子宫肌瘤组织中HMGA2、STAT3蛋白水平评估患者术后肌瘤复发价值  

Values of the levels of high mobility group A2 and signal transducer and activator of transcription 3 protein of patients with uterine fibroids for evaluating their postoperative recurrence

作　　者：林燕敏[1] 盛俊霞[1] Lin Yanmin;Sheng Junxia(The Second People's Hospital of Yuhang District,Hangzhou,Zhejiang Province,311121)

机构地区：[1]浙江省杭州市余杭区第二人民医院,311121

出　　处：《中国计划生育学杂志》2024年第5期1126-1130,共5页Chinese Journal of Family Planning

摘　　要：目的:探索子宫肌瘤患者肌瘤组织中高迁移率组蛋白A2(HMGA2)和信号转导与转录激活因子3(STAT3)蛋白水平与患者术后复发关系及评估价值。方法:选取2019年5月-2020年12月在本院接受腹腔镜子宫肌瘤剔除术治疗的子宫肌瘤患者168例,3年术后随访分为复发组(48例)及未复发组(120例)。收集患者一般资料,采用酶联免疫吸附实验检测患者术前血清孕酮(P)、黄体生成素(LH)、雌二醇(E_(2))、卵泡刺激素(FSH)及泌乳素(PRL)的水平,采用Western blot定量分析切除肌瘤组织中HMGA2、STAT3水平;受试者工作特征(ROC)曲线分析HMGA2、STAT3水平对子宫肌瘤患者术后复发的预测价值,多因素logistic回归分析其是否影响术后复发。结果:复发组血清P、LH、E_(2)、FSH、PRL水平高于未复发组,切除的肌瘤组织中HMGA2(1.42±0.28)、STAT3(1.33±0.24)水平均高于未复发组(1.03±0.21、1.02±0.18)(均P<0.05);ROC曲线分析显示,HMGA2联合STAT3评估患者术后肌瘤复发的曲线下面积(0.934)大于HMGA2(0.885)、STAT3(0.858)(均P<0.05)。多因素分析显示,术前血清P、FSH、PRL,以及肌瘤组织HMGA2、STAT3水平升高是子宫肌瘤患者术后复发的影响因素(均P<0.05)。结论:子宫肌瘤组织HMGA2、STAT3水平上调与术后复发有关,二者联合检测对辅助临床评估患者预后有较好价值。Objective:To explore the correlation between the levels of high mobility group A2(HMGA2)and signal transducer and activator of transcription 3(STAT3)protein of patients with uterine fibroids and their postoperative recurrence of uterine fibroids,and to study the values of the levels of HMGA2and STAT3of the patients for evaluating their postoperative recurrence of uterine fibroids.Methods:168patients with uterine fibroids who had undergone laparoscopic myomectomy in hospital from May 2019to Decemberb 2020and were followed up for 3years after surgery were selected in this study.These patients were divided into group A(48patients with the postoperative recurrence of uterine fibroids)and group B(120patients without the postoperative recurrence of uterine fibroids).The general information of the patients was collected.ELISA method was applied to detect the levels of serum progesterone(P),luteinizing hormone(LH),estradiol(E_(2)),follicle stimulating hormone(FSH),and prolactin(PRL)of the patients.Western blot was applied to quantitatively analyze the levels of HMGA2and STAT3in the excised uterine fibroids tissues.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic values of the HMGA2and STAT3 levels of the patients for their postoperative recurrence of uterine fibroids.Multivariate logistic regression was applied to analyze the influencing factors of the postoperative uterine fibroids recurrence of the patients.Results:The levels of serum P,LH,E_(2),FSH and PRL of the patients in group A were significantly higher than those of the patients in group B.The levels of HMGA2(1.42±0.28)and STAT3(1.33±0.24)in the excised uterine fibroids tissues of the patients in group A were significantly higher than those(1.03±0.21,1.02±0.18)of the patients in group B(all P<0.05).ROC curve analysis showed that the area under the curve(0.934)of the combined levels of HMGA2STAT3of the patients for predicting their postoperative uterine fibroids recurrence was significantly higher than that(0.885)of the HMGA2leve

关 键 词：子宫肌瘤 术后复发 肌瘤组织 高迁移率组蛋白A2 信号转导与转录激活因子3 评估 影响因素 

分 类 号：R737.33[医药卫生—肿瘤]