探讨胃“炎癌转化”中腐胺与巨噬细胞极化的关系  

Relationship between putrescine and macrophage polarization in gastric"inflammatory carcinoma transformation"

作　　者：孙虓 刘成霞[1] 王娜 郝佳慧 储琳琳 栗成钰 Sun Xiao;Liu Chengxia;Wang Na;Hao Jiahui;Chu Linin;Li Chengyu(Department of Gastroenterology and Institute of Digestive Diseases,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院消化内科滨州医学院附属医院消化病研究所,滨州256600

出　　处：《国际医药卫生导报》2024年第9期1426-1429,共4页International Medicine and Health Guidance News

基　　金：山东省教育厅“临床医学+X”学科建设项目资助课题(200375);山东省省级临床重点学科建设(SLCZDZK-13);滨州市科技发展计划(2015ZC0319)。

摘　　要：浅表性胃炎逐步发展到胃癌的这个过程称之为Correa级联反应。在Correa级联反应中,炎症阶段的炎性微环境和肿瘤细胞所处肿瘤微环境都发现有巨噬细胞的参与。而多胺,尤其是腐胺,与胃癌的发生、发展密切相关,并且多胺的代谢可以影响巨噬细胞的极化。近年来,腐胺与胃“炎癌转化”的关系及通过调控巨噬细胞的极化来干预癌症的发生和发展已成为研究热点。本文综述了近年来涉及胃癌、腐胺和巨噬细胞极化的相关研究,探讨胃“炎癌转化”过程中腐胺与巨噬细胞极化的关系,期望后续研究能通过调节腐胺代谢和巨噬细胞极化来达到预防或延缓胃癌发生、发展的目的。It gradually develops from superficial gastritis to gastric cancer,and this sequential process is called Correa cascade.In the Correa cascade,the involvement of macrophages was found both in the inflammatory microenvironment at the inflammatory stage and in the tumor microenvironment where tumor cells are located.Polyamines,especially putreamine,are also closely related to the occurrence and development of gastric cancer,and the metabolism of polyamines can affect the polarization of macrophages.In recent years,the relationship between putrescine and gastric"inflammation and cancer transformation"and the intervention of the occurrence and development of cancer by regulating the polarization of macrophages have become research hotspots.This article reviews the related researches on gastric cancer,putrescine,and macrophage polarization in recent years,and discusses the relationship between putrescine and macrophage polarization in the process of gastric"inflammation and cancer transformation".Subsequent studies are expected to achieve the purpose of preventing or delaying the occurrence and development of gastric cancer by regulating putrescine metabolism and macrophage polarization.

关 键 词：胃癌 胃“炎癌转化” 巨噬细胞极化 腐胺 进展 

分 类 号：R573.3[医药卫生—消化系统]