幽门螺杆菌粪便抗原检测在消化性溃疡初诊及治疗后复诊患者中的诊断价值  

Detection of Helicobacter pylori stool antigen in the initial diagnosis and treatment of peptic ulcer the value of application in the follow-up patients

作　　者：季善云 张卿 Ji Shanyun;Zhang Qing(Spleen and Stomach Department of Lianyungang City Hospital of Traditional Chinese Medicine,Lian Yungang 222000,China)

机构地区：[1]江苏省连云港市中医院脾胃科,222000

出　　处：《现代养生》2023年第18期1378-1380,共3页Health Protection and Promotion

基　　金：2020年南京医科大学康达学院科研发展基金立项课题(编号:KD2020KYJJYB026)。

摘　　要：目的 评价幽门螺杆菌粪便抗原检测在消化性溃疡患者初诊及治疗后复诊患者中的诊断价值。方法 选取2020年10月-2022年10月于医院检查胃镜后确诊为消化性溃疡的100例初诊患者及治疗后60例复诊患者(初诊患者中呼气试验阳性者经规范治疗结束后停药至少一月的患者)为研究对象。对初诊患者、治疗后的复诊患者进行呼气试验(13C或14C)及幽门螺杆菌粪便抗原检测。以呼气试验为金标准,评价幽门螺杆菌粪便抗原检测的诊断效果及其二者诊断结果的一致性。结果 以呼气试验为金标准,幽门螺杆菌粪便抗原对初诊患者幽门螺杆菌感染检测结果灵敏度95.35%、特异度85.71%,两方法检测结果比较,差异无统计学意义(P>0.05),并且具有高度一致性(Kappa=0.765);幽门螺杆菌粪便抗原对复诊患者幽门螺杆菌感染检测结果灵敏度80.0%、特异度88.0%,两方法检测结果比较,差异无统计学意义(P>0.05),并且具有中高度一致性(Kappa=0.586)。结论 HP粪便抗原检测与呼气试验检测HP感染的效果基本一致,具有较高的一致性,在消化性溃疡患者初诊及复诊时有一定价值。Objective To evaluate the consistency of the results of H.pylori stool antigen test and breath test test and its diagnostic value in primary and repeat patients after treatment.Methods 100 patients from October 2020 diagnosed with peptic ulcer after gastroscopy in October 2020 and 60 patients with positive breath test in the first treatment for at least one month after the end of standard treatment) were selected as the study subjects.The breath test(13C or 14C) and H.pylori stool antigen test of initial patients and return patients after treatment were used to evaluate the diagnostic effect of H.pylori stool antigen test by comparing the two diagnostic methods.Results Using the breath test as the gold standard,The sensitivity of Helicobacter pylori stool antigen for H.pylori infection was 95.35%,the specificity was 85.71%,Comparison of the test results between the two methods,Not statistically significant difference(P >0.05),And with high consistency(Kappa value=0.765);The sensitivity of H.pylori infection in patients was 80.0%,specificity 88.0%,Comparison of the test results between the two methods,Not statistically significant difference(P>0.05),And has a high consistency(Kappa value =0.586).Conclusion The effect of HP stool antigen test and HP infection has high consistency,and has certain value in the initial diagnosis and return visit of patients with peptic ulcer.

关 键 词：幽门螺杆菌 消化性溃疡 粪便抗原检测 初诊 

分 类 号：R573.1[医药卫生—消化系统] R446.5[医药卫生—内科学]