Relationships of body composition and adipocytokines with outcomes in metastatic castration-resistant prostate cancer patients receiving docetaxel chemotherapy  

作　　者：Jun-Hong Li Xing-Ming Zhang Xiao-Jie Bian Wei-Jie Gu Fang-Ning Wan Bo Dai Ding-Wei Ye 

机构地区：[1]Department of Urology,Fudan University Shanghai Cancer Center,Shanghai 200032,China [2]Shanghai Genitourinary Cancer Institute,Shanghai 200032,China

出　　处：《Asian Journal of Andrology》2023年第4期520-527,共8页亚洲男性学杂志（英文版）

基　　金：supported financially by the Medical Innovation Research Project of the Science and Technology Commission of Shanghai Municipality(20Y11905000);Natural Science Foundation of Science and Technology Commission of Shanghai Municipality(20ZR1412300);AoXiang Project of the Shanghai Anti-Cancer Association(SACA-AX202005).

摘　　要：We evaluated the relationships of body composition and serum adipocytokine levels with progression-free survival(PFS)and overall survival(OS)in metastatic castration-resistant prostate cancer(mCRPC)patients receiving docetaxel.The medical records of mCRPC patients who received docetaxel between January 2011 and December 2015 at Fudan University Shanghai Cancer Center(Shanghai,China)were reviewed.The following body composition parameters were calculated using computed tomography:skeletal muscle index(SMI),visceral adipose tissue index(VATI),and subcutaneous adipose tissue index(SATI).Pretreatment serum adipocytokine levels,including interleukin 6,insulin,leptin,monocyte chemoattractant protein-1,adiponectin,and resistin,were measured using the multiplex bead-based immunoassays.Cox regression and Kaplan–Meier methods were used for survival analyses.Of the 453 mCRPC patients initially identified,105 were included in the analysis.High VATI group patients had longer PFS(median,10 months vs 7 months,P=0.008)and OS(median,24 months vs 15 months,P=0.017),compared with low VATI group patients.SMI and SATI were not significantly associated with PFS or OS.Of the six detected adipocytokines,only leptin was associated with mCRPC prognosis.High leptin group patients had shorter PFS(median,7 months vs 12 months,P=0.0018)and OS(median,17 months vs 22 months,P=0.042),compared with low leptin group patients.Multivariate analysis showed that a high VATI was an independent protective factor for PFS and OS,while a high leptin level was an independent risk factor for PFS and OS.Therefore,VATI and serum leptin levels could provide important information concerning mCRPC prognosis.

关 键 词：ADIPOCYTOKINES body composition castration-resistant prostate cancer CHEMOTHERAPY PROGNOSIS 

分 类 号：R737.25[医药卫生—肿瘤]