手术范围和放疗对T2N0M01期甲状腺乳头状癌患者预后的影响  

Effects of surgical scope and radiotherapy on prognosis of patients with T2N0M01 thyroid papillary carcinoma

作　　者：高强 GAO Qiang(Department of Thyroid Vascular Surgery,Puyang Oilfield General Hospital,Puyang,Henan 457001,China)

机构地区：[1]濮阳油田总医院甲状腺血管外科,河南濮阳457001

出　　处：《医药论坛杂志》2024年第7期743-748,共6页Journal of Medical Forum

摘　　要：目的探讨手术范围和放疗对不同性别和年龄段T2N0M01期甲状腺乳头状癌(papillary thyroid carcinoma,PTC)患者预后的影响。方法应用回顾性研究方法,选取2008年7月—2012年3月濮阳油田总医院甲状腺血管外科收治及手术治疗的PTC患者417例,对比分析不同年龄段、不同性别PTC患者的10年生存率(OS),应用多变量COX回归分析T2N0M01期PTC患者预后的影响因素。结果(1)361例患者,10年全因生存310例,10年OS 85.87%;18~55岁患者,10年OS 90.91%;>55岁患者,10年OS 72.16%。男性10年OS 78.89%,女性10年OS 88.19%。(2)在>55岁的年龄段,无放疗+甲状腺全切除术(total thyroidectomy,TT)和无放疗+TT,均是影响患者预后的危险影响因素(P<0.05)。(3)男性患者,无放疗+TT和无放疗+TT,均是影响患者预后的危险影响因素(P<0.05)。结论对于T2N0M01期PTC患者,甲状腺全切除术联合放射治疗可提高年龄>55岁患者(男性+女性组合队列)和男性患者(年龄≥18岁)的10年OS。Objective To investigate the effect of surgical scope and radiotherapy on the prognosis of T2N0M01 stage PTC patients of different sex and age.Methods The retrospective study method was applied.Totally 417 patients with surgical treatment of PTC were selected from Puyang oil field general hospital thyroid vascular surgery during July 2008 to March 2012.The 10-year OS with PTC patients of different ages and genders was compared and analyzed.Multivariate COX regression was used to analyze the prognostic factors of T2N0M01 PTC patients.Results(1)Among 361 patients,310 were all cause survival in 10 years,and the OS was 85.87%in 10 years;Patients aged 18-55 years,10 years OS was 90.91%;>55 year old patient with OS 72.16% for 10 years.Male 10 years OS was 78.89%;Female 10 years OS was 88.19%.(2)In the age group>55 years old,no radiotherapy+TT and no radiotherapy+TT were risk factors affecting the prognosis of patients(P<0.05).(3)Male patients,no radiotherapy+TT and no radiotherapy+TT,were risk factors affecting the prognosis of patients(P<0.05).Conclusion For patients with T2N0M01 PTC,total thyroidectomy combined with radiotherapy can improve the 10-year OS of patients older than 55 years(male+female combined cohort)and male patients(age≥18 years).

关 键 词：手术范围 放疗 甲状腺乳头状癌 预后 

分 类 号：R736.1[医药卫生—肿瘤]