Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase  

作　　者：Xi Yang Changkun Pan Meitong Ye Jinshuo Liang Haoyang Cheng Qing Liang Shu Huang Jianshu Wang Hoi Yee Chow Haihuai He 

机构地区：[1]Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [3]Department of Neurosurgery,Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Journal of Genetics and Genomics》2024年第4期458-461,共4页遗传学报（英文版）

基　　金：supported by research grants from the National Natural Science Foundation of China(31871461 and 31671510 to H.H.).

摘　　要：The assembly of neurons into complex circuits relies upon appropriate axonal navigation to distant targets.Although considerable progress has been made toward understanding the regulation of the guidance and branching of axon extension,the molecular and cellular mechanisms underlying the coordination of the motility of the axon tip,axon growth,and branching remain largely unknown(Sudhof,2017).The Drosophila mushroom body(MB),the major site for associative learning and memory,is a powerful model system to investigate complex axon behaviors.The MB is a bilaterally symmetric central brain structure,mainly composed of Kenyon cells,MB output neurons,and dopaminergic neurons(Li et al.,2020).Among the seven neuronal subtypes of~2000 Kenyon cells,Y,a/β,and a/β'subtypes extend axons in a fascicle and bifurcate to produce two sister branches,one projecting into the dorsal lobe and the other into the medial lobe.

关 键 词：branching MEDIAL AXON 

分 类 号：Q25[生物学—细胞生物学]