口咽癌根治性调强放疗晚期不良反应研究进展  

Research progress in late toxicity of oropharyngeal cancer after radical intensity-modulated radiotherapy

作　　者：刘娅 周亚宁 左丹 易俊林 张烨 Liu Ya;Zhou Yaning;Zuo Dan;Yi Junlin;Zhang Ye(Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京100021

出　　处：《中华放射肿瘤学杂志》2024年第5期461-465,共5页Chinese Journal of Radiation Oncology

基　　金：中国癌症基金会北京希望马拉松专项基金(LC2020A16)。

摘　　要：调强放疗是口咽癌的根治性治疗手段,整体5年生存率为60%左右,而人乳头瘤病毒(HPV)相关患者的5年生存率更是高达80%。调强放疗后晚期不良反应常有发生,包括口干、吞咽困难、甲状腺功能减退、组织纤维化、放射性骨坏死和龋齿、后组脑神经损伤等,严重影响长期生存患者的生活质量。HPV相关口咽癌降低强度治疗的相关研究在国内外广泛开展,但其中对晚期反应关注较少。现对近年来调强放疗后晚期不良反应的发生、治疗、预测指标等相关研究进展进行综述,为降低强度治疗的放疗损伤研究提供参考,从而进一步优化综合治疗策略。Intensity-modulated radiotherapy(IMRT)is a radical treatment for oropharyngeal carcinoma.The 5-year overall survival(OS)is approximately 60%,and 80%for human papillomavirus(HPV)-related oropharyngeal carcinoma patients.Late toxicities after IMRT,including xerostomia,dysphagia,hypothyroidism,trismus,osteoradionecrosis and caries,and lower cranial neuropathy,seriously affect the quality of life of long-term survivors.The research on treatment de-intensification for HPV-related oropharyngeal cancer has been widely carried out at home and abroad,but there is little research focusing on late toxicity.In this article,related research progress in the incidence,treatment,prediction of late toxicity after IMRT was reviewed,aiming to provide reference for research on radiation-induced injury in de-intensification therapy research,thereby further optimizing comprehensive treatment strategies.

关 键 词：口咽肿瘤 放射疗法 调强适形 晚期反应 不良反应 

分 类 号：R739.63[医药卫生—肿瘤]