RNA选择性剪接对肿瘤细胞放射敏感性影响的研究进展  

Research progress in the effect of alternative splicing on radiosensitivity of cancer cells

作　　者：秦子凡 郑晓丽 刘康栋 葛红 Qin Zifan;Zheng Xiaoli;Liu Kangdong;Ge Hong(Department of Radiotherapy,Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital,Zhengzhou 450008,China;Department of Pathophysiology,Basic Medical College,Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属肿瘤医院,河南省肿瘤医院放疗科,郑州450008 [2]郑州大学基础医学院病理生理学系,郑州450000

出　　处：《中华放射肿瘤学杂志》2024年第5期479-484,共6页Chinese Journal of Radiation Oncology

摘　　要：放射治疗是恶性肿瘤最主要的治疗方式之一,放射敏感性是影响肿瘤患者放疗疗效的关键因素,也一直是研究的热点。选择性剪接是基因表达过程中转录后关键的调控步骤,选择性剪接可以使前体mRNA产生多种不同的剪接异构体,进而产生不同的蛋白质,它们在维持机体正常生命活动中起着至关重要的作用。肿瘤细胞相对正常细胞而言,有着更高比例的剪接失调事件发生。选择性剪接的失调,可以导致基因组不稳定性、血管生成等病理过程的发生,从而导致疾病的进展。肿瘤细胞中发生的异常剪接事件,可以作为新的治疗靶点。本文将对RNA选择性剪接、剪接事件与放射敏感性相关研究,以及研究展望进行综述。Radiation therapy is one of the most important treatment methods for malignant tumors.Radiosensitivity is the key factor affecting the therapeutic effect of radiation therapy for tumor patients,which has been a hot topic of research.Alternative splicing is a vital post-transcriptional regulatory step in the process of gene expression.It can produce a variety of different splicing isoforms of pre-mRNA,and then produce various proteins which play a crucial role in maintaining normal life activities of the body.Compared with normal cells,tumor cells have a higher proportion of splicing disorder events,which can lead to the occurrence of pathological processes such as genomic instability and angiogenesis,thus resulting in the progression of diseases.Abnormal splicing events occurring in tumors can be used as new therapeutic targets.In this article,RNA alternative splicing,splicing events affecting radiosensitivity,and the prospects were reviewed.

关 键 词：选择性剪接 剪接异构体 放射敏感性 

分 类 号：R730.55[医药卫生—肿瘤]