血清肿瘤标志物联合粪便隐血试验在大肠癌诊断中的价值  

Value of Serum Tumor Markers Combined with Fecal Occult Blood Test in Diagnosis of Colorectal Cancer

作　　者：赵换青 ZHAO Huan-qing(Department of Clinical Laboratory,Central Hospital of Jiaozuo Coal Industry(Group)Co.,Ltd.,Jiao-zuo,Henan 454000)

机构地区：[1]焦作煤业(集团)有限责任公司中央医院检验科,河南焦作454000

出　　处：《中国肛肠病杂志》2024年第4期5-8,共4页Chinese Journal of Coloproctology

摘　　要：目的:探究血清肿瘤标志物联合粪便隐血试验在大肠癌诊断中的价值,为临床上大肠癌的诊断提供理论依据。方法:选取2021年1月至2023年1月于本院就诊的60例大肠癌患者作为观察组,以我院同期就诊治疗的大肠疾病良性增生患者60例作为对照组,2组患者均进行血清肿瘤标志物检测、粪便隐血试验以及联合检测,比较3种检测方法的阳性检出率,2组患者的血清肿瘤标志物癌胚抗原(CEA)、糖类抗原50(CA50)、糖类抗原199(CA199)、糖类抗原724(CA724)水平,比较3种检测方法的灵敏度和特异度。结果:肿瘤标志物检测的阳性检出率为81.67%,粪便隐血试验检测的阳性检出率为68.33%,联合检测的阳性检出率为96.67%,联合检测的阳性检出率明显高于肿瘤标志物检测与粪便隐血试验的检出率(P<0.05)。观察组患者的血清肿瘤标志物水平明显高于对照组(P<0.05)。血清肿瘤标志物检测、粪便隐血试验、联合检测的灵敏度分别为81.67%、68.33%和96.67%,联合检测的灵敏度高于单项检测的灵敏度(P<0.05);血清肿瘤标志物检测、粪便隐血试验、联合检测的特异度分别为98.33%、96.67%和100.00%,3组患者的特异度比较差异无统计学意义(P>0.05),且联合检测的约登指数为0.97。结论:血清肿瘤标志物联合粪便隐血试验检测能够有效提高大肠癌患者的检出率,临床诊断价值较高。且2种检测方法操作简便,肿瘤标志物还有利于判断患者的病情,值得临床推广应用。Objective To explore the value of serum tumor marker detection combined with fecal occult blood test(FOBT)in the diagnosis of colorectal cancer,and to provide a theoretical basis for the clinical di-agnosis of colorectal cancer.Methods Total 60patients with colorectal cancer who were treated in our hospital from January 2021to January 2023were selected as the observation group,and 60patients with colorectal benign hyperplasia disease who were treated in our hospital at the same time were selected as the control group.Serum tumor marker detection,FOBT and combined detection were performed in both groups.The positive detection rates of the three detection methods were compared.The levels of serum tumor markers of carcinoembryonic antigen(CEA),carbohydrate antigen 50(CA50),carbohydrate antigen 199(CA199)and carbohydrate antigen 724(CA724)of the two groups were compared.The sensitivity and specificity of the three detection methods were compared.Results The positive detection rate of tumor marker detection was 81.67%,the positive detection rate of FOBT was 68.33%,and the positive detection rate of combined detection was 96.67%.The positive detection rate of combined detection was significantly higher than that of tumor marker detection and FOBT(P<0.05).The serum tumor marker level of the observation group was significantly higher than that of the control group(P<0.05).The sensitivities of serum tumor marker detection,FOBT,and combined detection were 81.67%,68.33%,and 96.67%,respec-tively.The sensitivity of combined detection was higher than that of single detection(P<0.05).The speci-ficity of serum tumor marker detection,FOBT and combined detection was 98.33%,96.67%and 100.00%,respectively.There was no significant difference in the specificity among the three groups of patients(P>0.05),and the Youden index of combined detection was 0.97.Conclusion Serum tumor marker detection combined with FOBT can effectively improve the detection rate of colorectal cancer patients,and has high clinical diagnostic value.The two dete

关 键 词：大肠癌 血清肿瘤标志物 粪便隐血试验 联合检测 诊断价值 

分 类 号：R735.34[医药卫生—肿瘤]