术中实施雷替曲塞腹腔灌注化疗对直肠癌患者术后并发症的影响  

Efct of Intraoperative Peritoneal Perfusion Chemotherapy with Raltitrexed on Postoperative Complications in Patients with Rectal Cancer

作　　者：李坤磊 娄梦思 王玉森 陈岩 LI Kun-lei;LOU Meng-si;WANG Yu-sen;CHEN Yan(First Affiliated Hospital of Henan University,Kaifeng,Henan 475000)

机构地区：[1]河南大学第一附属医院,河南开封475000

出　　处：《中国肛肠病杂志》2024年第4期17-19,共3页Chinese Journal of Coloproctology

基　　金：河南省医学科技攻关计划项目(课题编号:LHGJ20210554)。

摘　　要：目的:研究术中予以雷替曲塞腹腔灌注化疗对直肠癌患者术后并发症的影响。方法:选取2021年3月至2022年10月我院收治的直肠癌患者150例作为研究参与者,将其随机分为观察组和对照组,每组75例。对照组患者采用根治性切除术和腹腔灌注生理盐水治疗,观察组患者采用根治性切除术和术中雷替曲塞注射液灌注治疗,比较2组患者手术前后白细胞计数、血小板计数、谷丙转氨酶和肌酐水平;比较2组患者术后首次排气时间、住院时间;同时对患者出院后进行为期1年的随访,比较2组患者1年时的复发率以及2组患者术后吻合口漏、呕吐、发烧等并发症发生情况。结果:手术前后2组患者白细胞计数、血小板计数、谷丙转氨酶和肌酐水平比较差异无统计学意义(P>0.05);2组患者术后首次排气时间和住院时间比较差异无统计学意义(P>0.05);观察组患者复发率明显低于对照组(P<0.05);2组患者术后并发症发生率比较差异无统计学意义(P>0.05)。结论:对直肠癌患者术中予以雷替曲塞腹腔灌注化疗不会增加患者的毒副作用和不良反应,且能够有效降低患者术后复发率。Objectivee To study the effect of intraoperative peritoneal perfusion chemotherapy with raltitrexed on postoperative complications in patients with rectal cancer.MethodsTotal 150 patients with rectal cancer admitted to our hospital from March 2021 to October 2022 were selected as study participants and were randomly divided into observation group and control group,with 75 cases in each group.The control group was treated with radical resection and peritoneal perfusion of normal saline,and the observation group was treated with radical resection and intraoperative perfusion of raltitrexed injection.The white blood cell count,platelet count,alanine aminotransferase and creatinine levels before and after operation were compared between the two groups.The first postoperative exhaust time and hospital stay were compared between the two groups.At the same time,the patients were followed up for 1 year after discharge,and the recurrence rate of the two groups at 1 year and the occurrence of postoperative complications such as anastomotic leakage,vomiting and fever were compared between the two groups.ResultsThere was no significant difference in white blood cell count,platelet count,alanine aminotransferase and creatinine levels before and after operation between the two groups(P>0.05).There was no significant difference in the first exhaust time and hospital stay between the two groups(P>0.05).The recurrence rate of the observation group was significantly lower than that of the control group(P<0.05).There was no significant difference in the incidence of postoperative complications between the two groups(P>0.05).Conclusion Intraoperative peritoneal perfusion chemotherapy with raltitrexed for rectal cancer patients does not increase the toxic side effects and adverse reactions of patients,and can effectively reduce the postoperative recurrence rate of patients.

关 键 词：直肠癌 手术 雷替曲塞 腹腔灌注 复发 

分 类 号：R735.37[医药卫生—肿瘤]