Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture  

作　　者：Hongyan Qi Chunyan Hu Jie Zhang Lin Lin Shuangyuan Wang Hong Lin Xiaojing Jia Yuanyue Zhu Yi Zhang Xueyan Wu Mian Li Min Xu Yu Xu Tiange Wang Zhiyun Zhao Weiqing Wang Yufang Bi Meng Dai Yuhong Chen Jieli Lu 

机构地区：[1]Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China [2]Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of China,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China

出　　处：《Frontiers of Medicine》2024年第1期192-203,共12页医学前沿（英文版）

基　　金：supported by the Ministry of Science and Technology of China(No.2022YFC2505202);the National Natural Science Foundation of China(Nos.81970691 and 82170819);Shanghai Outstanding Academic Leaders Plan(No.20XD1422800);Shanghai Medical and Health Development Foundation(No.DMRFP_I_01);Clinical Research Plan of SHDC(No.SHDC2020CR3064B);Science and Technology Committee of Shanghai(No.20Y11905100);Key Medical Subject of Jiading District,Shanghai(No.2020-jdyxzdzk-01).

摘　　要：Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323 community-dwelling subjects aged⩾40 years from China.Early-life famine exposure was identified based on the participants’birth dates.General obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or lower.Compared to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in men.Significant interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.

关 键 词：FAMINE OBESITY body mass index waist-to-hip ratio low-energy fracture 

分 类 号：R589.2[医药卫生—内分泌]