精神分裂症认知与糖脂代谢和社会功能的关系  

Relationship between cognitive function,glucose and lipid metabolism and social function in schizophrenia

作　　者：唐开宏[1] 张沛云 刘超 严琦[1] 贺欣宇 周春英[1] TANG Kaihong;ZHANG Peiyun;LIU Chao(Second Department of Psychiatry,Nantong Fourth People's Hospital,Nantong 226000,China)

机构地区：[1]南通市第四人民医院精神二科,南通226000

出　　处：《国际精神病学杂志》2024年第2期378-381,共4页Journal Of International Psychiatry

基　　金：江苏省南通市卫生健康委员会面上课题(编号:MB2021065)。

摘　　要：目的探讨慢性精神分裂症认知功能特征和糖脂代谢与社会功能的关系,为患者的精神康复提供相应的理论依据。方法选取男性精神分裂症患者68例及健康对照组30例,完成一般情况调查表,应用重复性神经心理状态测验(Repeatable Battery for the Assessment of Neuropsychological Status,RBANS)、个人和社会功能量表(Personal and Social Performance scale,PSP)测评,研究组同时采集晨空腹血检测糖脂代谢指标。结果两组在年龄以及受教育年限方面均无显著差异(P>0.05)。研究组患者即刻记忆、视觉广度、言语功能、注意、延时记忆因子分及RBANS总分和PSP分均低于健康对照组(P<0.01)。Pearson相关分析显示,患者组RBANS总分与空腹血糖、甘油三酯水平呈负相关性(P<0.01)。患者组PSP评分与RBANS总分和各因子分均呈不同程度的正相关性(P<0.05或P<0.01)。多元逐步回归分析进一步显示,年龄、受教育年限及血糖可以影响患者的认知功能。结论男性慢性精神分裂症患者存在不同程度的认知功能和社会功能损害,认知功能与社会功能关系密切,血糖对认知功能有一定的影响。Objective To explore the cognitive functional characteristics and the relationship between glucose and lipid metabolism and social function in chronic schizophrenia,in order to provide corresponding theoretical basis for the mental rehabilitation of patients.Methods A total of 68 male patients with schizophrenia and 30 healthy controls were selected,to complete a self-made general condition questionnaire.Repeatable Battery for the Assessment of Neuro-psychological status(RBANS)to assess patients'cognitive function and Personaland Social Performancescale(PSP)on the social function of patients'with schizophrenia.At the same time,the morning abdominal blood was collected to detect the indexes of glucose and lipid metabolism.Results There was no significant difference in age and years of education between the two groups(P>0.05).The scores of immediate memory,visuospatial,language,attention,delayed memory and the total score of RBANS,as well as the PSP score of the study group patients were lower than those in the control group(P<0.01).Pearson correlation analysis showed thatthe RBANS total score in the patient group was negatively correlated with fasting blood glucose and triglyceride levels(P<0.01).The PSP score of the patient group showed varying degrees of positive correlation with the total RBANS score and various factor scores(P<0.05 or P<0.01).Multiple stepwise regression analysis further showed thatage,years of education,and blood sugar can affect patients'cognitive function.Conclusion Chronic schizophrenia patients have varying degrees of cognitive and social impairment.Cognitive function is closely related to social function,and blood sugar has a certain impact on cognitive function.

关 键 词：精神分裂症 认知 糖脂代谢 社会功能 男性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]