帕金森患者睡眠情况及其与焦虑、抑郁情绪的关系  

Study on sleep status and its relationship with anxiety and depression in patients with Parkinson's disease

作　　者：薛兵 黄珅 张冰[1] 常娜[1] 张建磊[1] 赵敏 XUE Bing;HUANG Shen;ZHANG Bing(Huaihe Hospital of Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学淮河医院,开封475000 [2]河南中医药大学第一附属医院

出　　处：《国际精神病学杂志》2024年第2期513-516,共4页Journal Of International Psychiatry

摘　　要：目的分析帕金森(Parkinson's disease,PD)患者睡眠情况及其与焦虑、抑郁情绪的关系。方法回顾性分析2020年1月~2022年12月在我院进行治疗的130例帕金森的临床资料,依据匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分将所有患者分为睡眠障碍(Sleep disorder,SD)组(n=88)、无SD组(n=42)。比较两组基线资料及各项评分[简易智能精神状态检查量表(Simple Intelligent Mental State Examination Scale,MMSE)、蒙特利尔认知评价量表(Montreal Cognitive Assessment Scale,MoCA)、统一帕金森病评定量表Ⅲ(Unified Parkinson's Disease Rating ScaleⅢ,UPDRS-Ⅲ)、汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)、汉密顿抑郁量表(Hamilton Depression Scale,HAMD)],用多因素Logistic回归分析帕金森患者SD的影响因素,采用Spearman相关系数分析帕金森患者PSQI评分与PDQ-8、UPDRS-Ⅲ、HAMA、HAMD评分的相关性。结果SD组多巴丝肼片等效剂量≥600 mg比例、PDQ-8、UPDRS-Ⅲ、HAMA、HAMD评分均高于无SD组(P<0.05);经多因素Logistic回归分析证实,多巴丝肼片等效剂量、PDQ-8、UPDRS-Ⅲ、HAMA、HAMD均为帕金森患者SD的危险因素,均P<0.05;相关性分析显示,首发帕金森患者PSQI评分与PDQ-8、UPDRS-Ⅲ、HAMA、HAMD呈正相关(P<0.05)。结论帕金森患者的SD发生率较高,且抑郁、焦虑、生活质量及运动障碍与帕金森患者的SD严重程度有关。Objective Sleep survey analysis of Parkinson's disease(PD)patients and its relationship with anxiety and depression.Method Retrospective analysis from January 2020 to December 2022 in our hospital for treatment of the clinical data of 130 patients with Parkinson's disease,according to the Pittsburgh sleep quality index(PSQI)score all patients were divided into sleep disorder(SD)group(n=88),SD(n=42).Baseline data and scores of the two groups were compared[Simple Intelligent Mental State Examination Scale(MMSE),Montreal Cognitive Assessment Scale(MoCA),Unified Parkinson's Disease Rating ScaleⅢ(UPDRS-Ⅲ),Hamilton Anxiety Scale(HAMA),and Hamilton Depression Scale(HAMD)].Multivariate Logistic regression was used to analyze the influencing factors of SD in PD patients.Spearman correlation coefficient was used to analyze the correlation between PSQI score and PDQ-8,UPDRS-Ⅲ,HAMA and HAMD scores in PD patients.Result The proportion of equivalent dose of dopamine hydrazine tablets≥600 mg,PDQ-8,UPDRSⅢ,HAMA,and HAMD scores in the SD group were higher than those in the non SD group(P<0.05).Multiple logistic regression analysis confirmed that the equivalent dose of dopamine hydrazine tablets,PDQ-8,UPDRS-Ⅲ,HAMA,and HAMD were all risk factors for SD in Parkinson's patients,with P<0.05.Correlation analysis showed that the PSQI score of first-onset Parkinson's disease patients was positively correlated with PDQ-8,UPDRSⅢ,HAMA,and HAMD(P<0.05).Conclusion The incidence of SD is higher in Parkinson's patients,and depression,anxiety,quality of life,and movement disorders are related to the severity of SD in Parkinson's patients.

关 键 词：帕金森 睡眠障碍 焦虑 抑郁 运动障碍 

分 类 号：R749.2[医药卫生—神经病学与精神病学]