Movement Trend Alterations in the Periaqueductal Gray(PAG)-Employed Ratbot Navigation Are Correlated with Stimulation Parameters  

作　　者：Sina Khajei Abed Khorasani Mohammad Reza Afarinesh Vahid Sheibani 

机构地区：[1]Neuroscience Research Center,Institute of Neuropharmacology,Kerman University of Medical Sciences,Kerman,7619813159,Iran [2]Cognitive Neuroscience Research Center,Institute of Neuropharmacology,Kerman University of Medical Sciences,Kerman,7616913555,Iran

出　　处：《Journal of Bionic Engineering》2024年第2期866-876,共11页仿生工程学报（英文版）

基　　金：“Kerman Neuroscience Research Center”for their full support in terms of providing the financial grant and the required instruments.

摘　　要：In previous studies,Periaqueductal Gray(PAG)stimulation was used to stop ratbots from moving.Due to the homology between the PAG and the intercollicular nucleus,which has been used for forward movement in birds,we investigated the possibility of PAG application to induce forward locomotion for the first time.Using a corridor maze,the traveled distances via PAG electrical stimulation were examined in nine Wistar male rats during three sessions.A custom-designed stimulator was developed to apply the stimulation.The results showed reductions in responses to stimulation over time.Accordingly,the traveled distances had negative slopes during the consecutive trials(in 8 out of the 9 rats),and the slope mean was significantly different from zero.There was a strong correlation between the stimulation parameters(electric Charge per Phase(CPP)and the Number of Pulses(NP))and the observed slopes.The negative Movement Slopes(MS)were highly correlated with the CPP and the NP,as the Pearson's linear correlation coefficients were−0.87 and−0.79,respectively.The MS-CPP coefficients of determination(R-squared)were also between 0.76 and 0.95.In addition,the MS-NP coefficients of determination were between 0.63 and 0.87.Thus,it is concluded that the electrical stimulation parameters influence the behavioral outcomes directly.Furthermore,the PAG area may be considered a suitable candidate for forward locomotion control in the future if the area is harnessed effectively to prevent undesirable chaotic behaviors.

关 键 词：Periaqueductal Gray(PAG) NAVIGATION Ratbot ANIMAL-ROBOT Forward locomotion Movement slope 

分 类 号：TP242[自动化与计算机技术—检测技术与自动化装置]