阿尔茨海默病患者血清中人β淀粉样蛋白1-42和人磷酸化tau-181蛋白的临床检测意义  

Clinical significance of detection of human amyloid β-peptide 1-42 and phosphorylated tau protein 181 in serum of patients with Alzheimer's disease

作　　者：郭静 赖于杨 罗晨辉 廖小叶 卢正优 GUO Jing;LAI Yu-yang;LUO Chen-hui(Department of Clinical Laboratory,Third Hospital of Longyan,Longyan 364000,China)

机构地区：[1]龙岩市第三医院检验科,364000

出　　处：《中国现代药物应用》2024年第9期68-70,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨阿尔茨海默病(AD)患者血清中人β淀粉样蛋白1-42(Aβ1-42)和人磷酸化tau-181蛋白(p-tau-181)的临床检测意义。方法选取60例AD患者作为AD组,依据简易智力状态检查表(MMSE)评分不同分为轻度AD组(20例)、中度及以上AD组(40例);选择同期进行体检的75例健康受试者作为健康对照组。对两组血清Aβ1-42和p-tau-181水平进行检测。比较AD组与健康对照组不同性别血清Aβ1-42和p-tau-18水平;AD组与健康对照组血清Aβ1-42和p-tau-18水平;AD组不同严重程度血清Aβ1-42和p-tau-18水平。结果健康对照组中男性受试者血清Aβ1-42和p-tau-18水平与女性比较,差异均无统计学意义(P>0.05)。AD组中男性患者血清Aβ1-42和p-tau-18水平与女性比较,差异均无统计学意义(P>0.05)。AD组血清Aβ1-42和p-tau-18水平分别为(102.0±12.3)、(22.1±6.9)pg/ml,显著高于健康对照组的(33.7±10.6)、(10.9±7.1)pg/ml,差异有统计学意义(P<0.05)。中度及以上AD组血清Aβ1-42和p-tau-18水平分别为(108.2±11.1)、(25.3±7.3)pg/ml,高于轻度AD组的(89.6±9.8)、(15.7±8.6)pg/ml,差异有统计学意义(P<0.05)。结论AD患者中血清Aβ1-42和p-tau-181均呈高表达,且其浓度与AD患者病情严重程度呈正相关。Objective To explore the clinical significance of detection of human amyloidβ-peptide 1-42(Aβ1-42)and phosphorylated tau protein 181(p-tau-181)in serum of patients with Alzheimer's disease(AD).Methods 60 AD patients were served as the AD group,and were divided into the mild AD group(20 cases)and the moderate and above AD group(40 cases)based on the different scores of the Mini-Mental Status Examination(MMSE)score;75 healthy subjects who underwent a physical examination at the same time were selected as the healthy control group.Serum Aβ1-42 and p-tau-181 levels were measured in both groups.Comparison was made on serum Aβ1-42 and p-tau-18 levels of different genders between AD group and healthy control group,serum Aβ1-42 and p-tau-18 levels between AD group and healthy control group,and serum Aβ1-42 and p-tau-18 levels of patients with different severity in the AD group.Results There were no significant differences in serum Aβ1-42 and P-TAU-18 levels between male and female subjects in healthy control group(P>0.05).There were no significant differences in serum Aβ1-42 and P-taU-18 levels between male and female patients in AD group(P>0.05).The serum levels of Aβ1-42 and P-taU-18 in AD group were(102.0±12.3)and(22.1±6.9)pg/ml,which were significantly higher than(33.7±10.6)and(10.9±7.1)pg/ml in healthy control group,and the difference was statistically significant(P<0.05).Serum levels of Aβ1-42 and p-taU-18 in moderate and above AD group were(108.2±11.1)and(25.3±7.3)pg/ml,which were higher than(89.6±9.8)and(15.7±8.6)pg/ml in mild AD group,and the difference was statistically significant(P<0.05).Conclusion Serum Aβ1-42 and p-tau-181 are highly expressed in AD patients,and their concentrations are positively correlated with severity of condition of AD patients.

关 键 词：阿尔茨海默病 人β淀粉样蛋白1-42 人磷酸化tau-181蛋白 

分 类 号：R749.16[医药卫生—神经病学与精神病学]