烟酸对脑梗死患者介入治疗后血流状态和神经功能及预后的影响  

Effect of niacin on blood flow status,neurological function and prognosis of patients with cerebral infarction after interventional therapy

作　　者：王丽[1] 赵梓喆 辛玉甫[3] 黄丽娜[4] WANG Li;ZHAO Zi-zhe;XIN Yu-fu;HUANG Li-na(Department of Pharmacy,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;College of Basic Medicine and Forensic Medicine,Henan University of Science and Technology,Luoyang,Henan 471000,China;Department of Rehabilitation Medicine,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000,China;Department of Neurology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000,China)

机构地区：[1]河南科技大学第一附属医院药学部,河南洛阳471000 [2]河南科技大学基础医学与法医学院,河南洛阳471000 [3]河南科技大学第一附属医院康复医学科,河南洛阳471000 [4]河南科技大学第一附属医院神经内科,河南洛阳471000

出　　处：《医药论坛杂志》2024年第8期873-877,共5页Journal of Medical Forum

基　　金：河南省医学科技攻关计划项目(LHGJ20220676)。

摘　　要：目的探讨烟酸对脑梗死(ACI)患者介入治疗后血流状态、神经功能及预后的影响。方法选取2021年1月—2022年12月收治的ACI患者86例,随机分为对照组(43例,支架置入术+术后常规治疗)与观察组(43例,给予支架置入术+术后常规治疗+烟酸静脉滴注),比较两组脑血流灌注、神经功能及随访90 d预后情况。结果观察组治疗后颈总动脉血流速度、颈内动脉血流速度、椎动脉血流速度分别为(52.47±4.59)cm/s、(52.84±3.48)cm/s、(45.78±4.13)cm/s,均大于对照组的(48.86±4.27)cm/s、(49.62±3.26)cm/s、(41.74±3.97)cm/s,颈总动脉阻力指数、颈内动脉阻力指数、椎动脉阻力指数分别为(0.62±0.04)、(0.60±0.06)、(0.59±0.07),均小于对照组的(0.68±0.07)、(0.65±0.05)、(0.63±0.08)(P<0.05);治疗后观察组NIHSS为(6.69±1.15)分,低于对照组的(7.86±1.47)分,BDNF、NGF分别为(5.27±0.89)μg/L、(146.82±12.74)μg/L,均高于对照组的(4.32±0.77)μg/L、(133.76±14.27)μg/L(P<0.05);随访90 d,观察组mRS评分为(2.67±0.61)分,低于对照组的(3.17±0.57)分(P<0.05)。结论术后加用烟酸可提高ACI介入治疗患者脑血流灌注,改善神经功能及短期预后。Objective To investigate the effects of niacin on blood flow status,neurological function and prognosis of patients with cerebral infarction(ACI)after interventional therapy.Methods Totally 86 ACI patients admitted from January 2021 to December 2022were randomly divided into control group(43 cases,stent implantation+conventional postoperative treatment)and observation group(43 cases,stent implantation+conventional postoperative treatment+niacin intravenous infusion).Cerebral blood perfusion,neurological function and prognosis of the two groups were compared after 90 days of follow-up.Results After treatment,the blood flow velocity of common carotid artery,internal carotid artery and vertebral artery in observation group were(52.47±4.59)cm/s,(52.84±3.48)cm/s,(45.78±4.13)cm/s,respectively,which were higher than those in control group(48.86±4.27)cm/s,(49.62±3.26)cm/s,(41.74±3.97)cm/s(P<0.05),The common carotid artery resistance index,internal carotid artery resistance index and vertebral artery resistance index in observation group were(0.62±0.04),(0.60±0.06)and(0.59±0.07),respectively,which were lower than those in control group(0.68±0.07),(0.65±0.05)and(0.63±0.08)(P<0.05).After treatment,NIHSS in observation group was(6.69±1.15)points,lower than that in control group(7.86±1.47)points,BDNF,NGF in observation group were(5.27±0.89)μg/L,(146.82±12.74)μg/L,respectively,which were higher than those in control group(4.32±0.77)μg/L,(133.76±14.27)μg/L(P<0.05).After 90 days of follow-up,the mRS Score of observation group was(2.67±0.61),which was lower than that in control group(3.17±0.57)(P<0.05).Conclusion The addition of niacin after surgery can improve cerebral blood perfusion,neurological function and short-term prognosis of patients treated with ACI.

关 键 词：烟酸 脑梗死 神经功能 预后 脑血流 介入治疗 支架置入术 

分 类 号：R743.33[医药卫生—神经病学与精神病学]