基于呋喃环结构及CYP3A4*1G和ABCB1基因多态性探讨川楝素致肝毒性机制  

Analysis of hepatotoxicity mechanism of Toosendanin based on furan ring structure and CYP3A4*1G and ABCB1 gene polymorphism

作　　者：黄敏 霍艳飞 鞠永静 陈亚飞 邱健珉 谢彦军[2] HUANG Min;HUO Yanfei;JU Yongjing;CHEN Yafei;QIU Jianmin;XIE Yanjun(Department of Emergency,Linyi Central Hospital of Shandong Province,Linyi,Shandong 276400,China;Shandong Adverse Drug Reaction Monitoring Center,Jinan,Shandong 250014,China;Pharmacovigilance Center of Linyi City,Linyi,Shandong 276000,China)

机构地区：[1]山东省临沂市中心医院急诊科,山东临沂276400 [2]山东省药品不良反应监测中心,山东济南250014 [3]山东省临沂市药物警戒中心,山东临沂276000

出　　处：《医药前沿》2024年第15期60-61,65,共3页Journal of Frontiers of Medicine

基　　金：山东省药品不良反应监测中心、山东省药物滥用监测中心课题(2022SDADRKY20)。

摘　　要：川楝素是川楝子的有效成分,也是产生急性毒性、消化系统和生殖系统毒性等不良反应的物质基础,川楝子是乳块消片/颗粒的七种组分之一。本文通过分析川楝素结构特点、CYP3A4*1G和ABCB1基因多态性,探讨川楝素导致肝毒性的毒理作用机制,为川楝素的安全用药提供建议。Toosendanin is an effective component of Toosendana,and also the material basis of acute toxicity,toxicity of digestive system and reproductive system.In this study,the mechanism of hepatotoxicity induced by Toosendanin was investigated by analyzing the structural characteristics of azadirachtin,CYP3A4*1G and ABCB1 gene polymorphism,so as to provide suggestions for the safe use of azadirachtin.

关 键 词：川楝素 肝毒性 基因多态性 CYP3A4 CYP3A4*1G ABCB1 

分 类 号：R575[医药卫生—消化系统]