松果体区肿瘤放射治疗:29例单中心经验分析  

Radiation Therapy for Tumors in the Pineal Region:A Single-Center Experience of 29 Cases

作　　者：王朵朵 姜雪松[1] 李雨桃 刘迎新 刘雅恬[1] WANG Duoduo;JIANG Xuesong;LI Yutao;LIU Yinxin;LIU Yatian(Cancer Hospital Affiliated to Nanjing Medical University,Jiangsu Cancer Hospital,Jiangsu Cancer Institute,Nanjing 210009,China)

机构地区：[1]南京医科大学附属肿瘤医院,江苏省肿瘤医院,江苏省肿瘤防治研究所,江苏南京210009

出　　处：《肿瘤学杂志》2024年第3期225-230,共6页Journal of Chinese Oncology

摘　　要：[目的]观察松果体区肿瘤放射治疗的疗效及预后,并探讨不同放疗方案的疗效差异。[方法]回顾性分析2008年4月至2022年9月在江苏省肿瘤医院接受首次放疗的29例松果体区肿瘤患者的临床资料,其中局部放疗10例、全脑室+局部加量放疗4例、全脑+局部加量放疗3例,以及全脑全脊髓+局部加量放疗12例。采用Kaplan-Meier法分析总生存率及无进展生存率并绘制生存曲线。[结果]29例患者3、5和10年总生存率分别为92.5%、92.5%和74.0%,3、5和10年无进展生存率分别为88.6%、88.6%和79.8%。29例患者中4例复发,分别为局部放疗组1例、全脑室+局部加量放疗组2例、全脑+局部加量放疗组1例。4例复发患者中3例死亡,其中全脑+局部加量放疗组1例,全脑室+局部加量放疗2例。另1例复发患者在局部放疗后出现颅内复发,但通过全脑全脊髓照射后成功挽救。[结论]放射治疗是大多数松果体区肿瘤的多学科治疗方法的基本组成部分,对于预后较差的患者,全脑全脊髓放疗可能有更好的疾病控制。[Objective]To observe the therapeutic efficacy and prognosis of radiotherapy for pineal region tumor and to explore the differences in therapeutic efficacy between different radiotherapy regimens.[Methods]Clinical data of 29 patients with pineal region tumor receiving initial radiotherapy at Jiangsu Cancer Hospital from April 2008 to September 2022 were retrospectively analyzed,including 10 cases of primary site radiotherapy(PSRT),4 cases of whole brain+primary boost radiotherapy(WBRT+PB),3 cases of whole ventricle+primary boost radiotherapy(WVI+PB),and 12 cases of craniospinal irradiation+primary boost radiotherapy(CSI+PB).The overall survival and progression-free survival were analyzed by Kaplan-Meier method and survival curve was drawn.[Results]The overall survival of 29 patients at 3-year,5-year and 10-year were 92.5%,92.5%and 74.0%,respectively.The 3-year,5-year and 10-year progression-free survival rates were 88.6%,88.6%and 79.8%,respectively.Among the 29 patients,4 experienced recurrence,including 1 case in PSRT group,1 cases in WBRT+PB group and 2 case in WVI+PB radiotherapy group.Among the 4 recurrence patients,3 cases died,including 2 case in the WVI+PB group and 1 cases in WBRT+PB group.Additionally,1 case experienced intracranial recurrence after primary site radiotherapy but was successfully salvaged through whole brain and whole spinal cord irradiation.[Conclusion]Radiotherapy is a fundamental component of the multidisciplinary treatment approaches for most pineal region tumors.For patients with a poorer prognosis,whole brain and whole spinal cord irradiation may have superior disease control,comparatively.

关 键 词：松果体瘤 放射疗法 脊髓 脑 

分 类 号：R739.41[医药卫生—肿瘤]