Efficacy and safety of extracorporeal shock wave therapy combined with sodium hyaluronate in treatment of knee osteoarthritis:a systematic review and Meta-analysis  

作　　者：ZHOU Mingwang DONG Zhuanli WEI Changhao FENG Lufang WANG Xiaoping LIU Haiping JI Xing YANG Kehu LI Shenghua 

机构地区：[1]Department of Orthopaedics,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China [2]Department of Quality Management,Lanzhou Petrochemical General Hospital,Lanzhou 730050,China [3]Department of Orthopaedics,Lanzhou Petrochemical General Hospital,Lanzhou 730050,China [4]Evidence-Based Social Science Research Center,School of Public Health,Lanzhou University,Lanzhou,730000,China [5]Evidence-Based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China [6]Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province,Lanzhou 730000,China [7]Center for Translational Medicine,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China [8]Department of Orthopaedics,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China

出　　处：《Journal of Traditional Chinese Medicine》2024年第2期243-250,共8页中医杂志（英文版）

基　　金：Natural Science Foundation-funded Project:Yang Deficiency Constitution of Knee Osteoarthritis and the Wnt/β-catenin Signaling Pathway Regulates the Level of Correlation,and the Constitution Theraphy(No.81260546);Construction Project of Chinese Medicine Inheritance Innovation Platform:Basic and Clinical Application Research on Osteoarthritis of the Knee(Gan Wei Chinese Medicine Letter[2020]No.203);Gansu Provincial Science and Technology Plan Project:Clinical Medical Research Centre for Bone and Joint Degenerative Diseases(18JR2FA009)。

摘　　要：OBJECTIVE:To assess the efficacy and safety of extracorporeal shockwave therapy(ESWT)combined with sodium hyaluronate(HA)for the treatment of knee osteoarthritis(KOA).METHODS:PubM ed,Embase,the Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang database,China Science and Technology Journal Database,and SinoMed were searched from inception to July 2020.The quality of the randomized controlled trials was evaluated independently by two reviewers according to the criteria in the Cochrane Collaboration for Systematic Reviews.The identified articles were then screened individually using EndnoteX9 for eligibility in this Meta-analysis.The heterogeneity among the articles was evaluated using I2.RESULTS:A total of 17 studies,comprising 2000 individuals,were included in this Meta-analysis.The results showed that a significant improvement was observed in knee pain and function based on the clinical efficacy of ESWT combined with HA.Statistical analysis of clinical efficacy showed that[relative risk(RR)=1.21,95%confidence interval(CI)(1.12,1.30),P<0.01].Statistical analysis of visual analog scale showed that[standardized mean difference(SMD)=-2.84,95%CI(-4.01,-1.66),P<0.01].Western Ontario and McMaster University osteoarthritis index statistical analysis showed that[SMD=-1.57,95%CI(-2.52,-0.61),P<0.01].Lysholm score statistical analysis showed that[SMD=1.71,95%CI(0.98,2.44),P<0.01].In addition,only minor side effects,such as redness and swelling of the skin,were observed.CONCLUSIONS:Medium to low quality evidence showed that ESWT combined with HA offers an inexpensive,welltolerated,safe,and effective method to improve pain and functionality in patients with KOA.However,tightly controlled,randomized,large multicenter trials are warranted to validate the current findings.

关 键 词：OSTEOARTHRITIS KNEE randomized controlled trial extracorporeal shockwave therapy hyaluronic acid META-ANALYSIS 

分 类 号：R684.3[医药卫生—骨科学]