芬吗通联合艾司奥美拉唑治疗对围绝经期妇女胃食管反流病的疗效  

Analysis Clinical Effect of Femoston with Esomeprazole Treatment on GERD in Perimenopausal Women

作　　者：阿米娜·沙吾提[1] 阿孜古丽·阿力木江 买买提·依斯热依力 王婧[1] 阿巴伯克力·乌斯曼 陈美华[1] 陆萍[1] 克力木·阿不都热依木[2] Amina·Shawuti;Aziguli·Alimujiang;Maimaiti·Yisireyili;Wang Jing;Ababokeli·Wusiman;Chen Meihua;Lu Ping;Kelimu·Abudureyimu;无(Department of Obstetrics and Gynecology Clinic;Research Institute of Minally Invasive Surgery;Research Center of Clinical Medecine,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院妇科,乌鲁木齐830001 [2]新疆维吾尔自治区人民医院自治区普外微创研究所,乌鲁木齐830001 [3]新疆维吾尔自治区人民医院医学研究与转化中心,乌鲁木齐830001

出　　处：《中华胃食管反流病电子杂志》2021年第3期123-128,共6页Chinese Journal Of Gastroesophageal Reflux Disease(Electronic Edition)

基　　金：新疆维吾尔自治区人民医院院内项目(20200111)。

摘　　要：目的探讨围绝经期妇女胃食管反流病(GERD)的临床特征及芬吗通联合艾司奥美拉唑治疗围绝经期合并GERD的临床效果。方法回顾性分析自2020年3月至2021年3月于新疆维吾尔自治区人民医院妇科门诊及微创外科就诊的80例围绝经期GERD患者。依照治疗方式的不同分为对照组和观察组,各40例。对照组给予艾司奥美拉唑抑酸治疗;观察组在对照组的基础上联合给予雌二醇/雌二醇地屈孕酮(芬吗通),2组均连续治疗6个月。采用Kupperman问卷调查(围绝经期症状评分)、GERD问卷调查、胃酸24 h pH监测、高分辨率食管动力监测以及激素水平检测等方法来分析2组治疗前后抑酸和改善绝经期症状的效果。结果观察组围绝经期症状Kupperman评分及GERD症状评分的降低程度显著低于对照组(P<0.05)。2组治疗前与治疗后食管近端弱酸反流比值、食管近端酸反流比值及DeMeester评分等,均显著降低(P<0.05)。2组治疗前与治疗后食管下段括约肌(LES)静息压以及食管远端收缩积分(DCI),均显著上升(P<0.05),提示2组抑酸治疗对酸反流及食管功能的疗效相当。观察组治疗后显著降低促黄体生成素(LH)和促卵泡生成激素(FSH)水平(P<0.05);同时雌二醇(E2)的水平显著上升(P<0.05)。观察组治疗后疗效明显高于对照组(P<0.05);而其无效率显著低于对照组(P<0.05)。观察组用药后出现的头疼、恶心、呕吐以及乳房胀痛等药物不良反应发生情况均明显低于对照组(P<0.05)。结论该联合治疗对围绝经期GERD的疗效较好,可显著改善围绝经期及GERD症状的发生,值得临床诊治中进一步推广应用。Objective To analyze the clinical aspects of perimenopausal women with gastroesophageal reflux disease(GERD)andthe clinical effects of femoston combined with esomeprazole in the treatment of perimenopausal women with GERD.Methods A retrospective study made on 80 patients whom with perimenopausal GERD between March 2020 to March 2021 in our hospital were analyzed.According to different treatment methods,all patients was grouped as control(n=40)and observation(n=40);the control group was treated with esomeprazole;the observation group was given femoston that on the basis of esomeprazole,and the two groups were treated for 6 months.Kupperman questionnaire,GERD questionnaire,24-h pH monitoring of gastric acid,high-resolution esophageal motilityand sex hormones wereused to analyze the clinical effects of that combination therapy.Results The perimenopausal symptom score and GERD score of theobservation groups were markedly decline than pre treatment(P<0.05);compared with before treatment,the levels of proximal esophageal weak acid reflux(%),proximal esophageal acid reflux(%)and Demeester score decreased significantly after treatment(P<0.05);the resting pressure of lower esophageal sphincter(LES)and DCI increased significantly after treatment compared with those before treatment(P<0.05);the levels of luteinizing hormone(LH)and follicle stimulating hormone(FSH)were significantly decrease in the observation group after treatment(P<0.05);at the same time,the level of estradiol(E2)was significantly increased(P<0.05);the clinical efficacy of the observation group was excellent than that of the control group(P<0.05);the ineffective rate of the observation group was markedly lower(P<0.05);the incidence of adverse drug reactions such as headache,nausea,vomiting and breast pain in the observation group was significantly lower than that in the control group(P<0.05).Conclusion The combined therapy has a good effect on perimenopausal with GERD,and can significantly improve the occurrence of perimenopausal and GERD symptoms,that is

关 键 词：胃食管反流病 围绝经期妇女 症状 奥美拉唑 芬吗通 

分 类 号：R57[医药卫生—消化系统]