复发性口腔溃疡患者食物不耐受特异性IgG抗体检测特征分析  

Characterization of food intolerance-specific IgG antibody test in patients with recurrent oral ulcers

作　　者：杨艳杰[1] 焦静 王静[1] YANG Yanjie;JIAO Jing;WANG Jing(Department of Stomatology,Zhengzhou University First Affiliated Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州大学第一附属医院口腔科,河南郑州450000

出　　处：《临床研究》2024年第6期37-40,共4页Clinical Research

摘　　要：目的分析复发性口腔溃疡(ROU)患者食物不耐受特异性免疫球蛋白G(IgG)抗体检测特征结果,以期为ROU患者对食物不耐受的诊断和治疗提供依据。方法采用回顾性分析,选取2020年1月至2023年12月在郑州大学第一附属医院门诊就诊的1975例ROU患者为研究对象,收集患者的一般资料,统计患者食物不耐受特异性IgG抗体检测结果,比较不同年龄、不同性别患者食物不耐受的抗体检测结果差异。结果血清IgG阳性率最高的前5种食物分别是鸡蛋(47.34%)、牛奶(31.14%)、小麦(21.87%)、大豆(21.22%)、西红柿(10.38%),其中牛肉(0.46%)、猪肉(0.56%)、鸡肉(1.37%)、虾(1.82%)的血清IgG阳性率较低。女性受试者对鳕鱼、鸡蛋、牛奶3种食物的不耐受阳性率显著高于男性,差异有统计学意义(P<0.05)。不同年龄患者在鸡肉、鳕鱼、鸡蛋、蘑菇、牛奶、虾、大豆、小麦8种食物中的不耐受阳性率差异有统计学意义(P<0.05);未成年组对鸡蛋、牛奶、大豆、小麦4种食物的不耐受阳性率高于中青年组和老年组,对虾、蘑菇的不耐受阳性率低于中青年组和老年组,对鸡肉的不耐受阳性率显著高于中青年组,对鳕鱼的不耐受阳性率显著高于老年组,差异有统计学意义(P<0.05)。结论ROU患者发生食物不耐受的概率较高,食物不耐受与患者的性别和年龄有一定关系,及早对ROU患者进行食物血清特异性IgG抗体检测,可及时发现患者不耐受的食物以调整饮食,避免食源性的机体免疫反应。Objective To analyze the results of food intolerance-specific immunoglobulin G(IgG)antibody detection characteristics in patients with recurrent oral ulcers(ROU),with a view to providing a basis for the diagnosis and treatment of food intolerance in patients with ROU.Methods A retrospective analysis was employed to identify 1975 ROU patients who had attended outpatient clinics at Zhengzhou University First Affiliated Hospital between January 2020 and December 2023.This process involved the collection of general data on the patients,the statistical analysis of the results of their food intolerance-specific IgG antibody tests,and the comparison of the antibody test results for food intolerance in patients of different ages and genders.Results The five foods with the highest serum IgG positivity were egg(47.34%),milk(31.14%),wheat(21.87%),soybeans(21.22%),and tomatoes(10.38%),with lower serum IgG positivity in beef(0.46%),pork(0.56%),chicken(1.37%),and shrimp(1.82%).The positive intolerance rate of three foods,cod,egg,and milk,was significantly higher in female subjects than in males.This difference was statistically significant(P<0.05).The differences in the positive rates of intolerance to eight foods,namely chicken,cod,egg,mushroom,milk,shrimp,soybean,and wheat,among patients of different ages were statistically significant(P<0.05).The positive rates of intolerance to four foods,namely egg,milk,soybean,and wheat,were higher in the immature group than in the middle-aged and elderly groups.Conversely,those of shrimp and mushrooms were lower than those in the middle-aged and elderly groups.The positive rates of intolerance to chicken were significantly higher than those of the young and middle-aged groups,and the positive rates of intolerance to cod were significantly higher than those of the elderly group.These differences were statistically significant(P<0.05).The intolerance positive rates of chicken,cod,egg,mushroom,milk,shrimp,soybean,and wheat were statistically significantly different between the young and mi

关 键 词：复发性口腔溃疡 食物不耐受 特异性免疫球蛋白G抗体 性别 年龄 

分 类 号：R364.16[医药卫生—病理学]