Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning  

作　　者：Ping WANG Congying SONG Xuan LU Yuanqiang LU 

机构地区：[1]Department of Emergency Medicine,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 3100030 China [2]Zhejiang Key Laboratory for Diagnosis and Treatment of Physic chemical and Aging related Injuries,Hangzhou 310003,China [3]Department of Geriatric Medicine,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第4期354-358,共5页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Key Research and Development Program of Zhejiang Province(No.2019C03076),China。

摘　　要：Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the world.Glufosinate-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity of glutamine synthetase(GS)and Glu decarboxylase in plants,thereby blocking the synthesis of glutamine(Gln)from Glu and ammonia(Hoerlein,1994).This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia.In humans,the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity(Watanabe and Sano,1998).

关 键 词：AMMONIUM ammonia thereby 

分 类 号：R742.1[医药卫生—神经病学与精神病学]