全入肝血流阻断与半肝入肝血流阻断对行腹腔镜肝切除术的原发性肝癌患者免疫功能的影响  

Effect of Total Hepatic Blood Flow Blockade and Semi-hepatic Blood Flow Blockade on Immune Function in Patients with Primary Liver Cancer undergoing Laparoscopic Hepatectomy

作　　者：郭耀 王新建 Guo Yao;Wang Xinjian(Department of Clinical Medicine,Jinzhou Medical University,Jinzhou 121000,Liaoning Province,China;Department of Hepatobiliary Surgery,Weihai Central Hospital,Weihai 264400,Shandong Province,China)

机构地区：[1]锦州医科大学临床医学系,辽宁锦州121000 [2]威海市中心医院肝胆外科,山东威海264400

出　　处：《中国社区医师》2024年第11期57-59,共3页Chinese Community Doctors

摘　　要：目的:分析全入肝血流阻断与半肝入肝血流阻断对行腹腔镜肝切除术的原发性肝癌患者免疫功能的影响。方法:选取2022年12月-2023年12月于威海市中心医院行肝切除术的原发性肝癌患者63例作为研究对象,随机分为对照组(n=31)、观察组(n=32)。对照组实施全入肝血流阻断,观察组实施半肝入肝血流阻断。比较两组T淋巴细胞亚群、免疫活性物质水平。结果:术前术后,两组CD19^(+)水平比较,差异无统计学意义(P>0.05);术后,两组CD19^(+)水平低于术前,差异有统计学意义(P<0.05);术前,两组CD4^(+)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05);术后,两组CD4^(+)、CD4^(+)/CD8^(+)水平低于术前,但观察组高于对照组,两组CD8^(+)水平低于术前,且观察组低于对照组,差异有统计学意义(P<0.05)。术前,两组免疫球蛋白G(IGG)、血清免疫球蛋白A(IGA)、血清免疫球蛋白M(IGM)、补体C3、补体C4水平比较,差异无统计学意义(P>0.05);术后,对照组IGG、IGA、IGM水平低于术前,观察组IGG、IGA、IGM、补体C3、补体C4水平高于对照组,差异有统计学意义(P<0.05)。结论:相较于全入肝血流阻断,半肝入肝血流阻断对行腹腔镜肝切除术的原发性肝癌患者免疫功能的影响更小,有利于术后免疫功能恢复。Objective:To analyze the effects of total hepatic blood flow blockade and semi-hepatic blood flow blockade on immune function in patients with primary liver cancer undergoing laparoscopic hepatectomy.Methods:Sixty-three patients with primary liver cancer who underwent hepatectomy in Weihai Central Hospital from December 2022 to December 2023 were selected as the study objects,and randomly divided into control group(n=31)and observation group(n=32).The control group was subjected to total hepatic blood flow blockade,and the observation group was subjected to semi-hepatic blood flow blockade.T lymphocyte subsets and immunoactive substance levels were compared between the two groups.Results:There was no significant difference in CD19^(+)level between the two groups before and after operation(P>0.05);after operation,CD19^(+)level was lower than before operation,the difference was statistically significant(P<0.05);before surgery,there was no significant difference in the levels of CD4^(+)and CD4^(+)/CD8^(+)between 2 groups(P>0.05);after surgery,the levels of CD4^(+)and CD4^(+)/CD8^(+)in both groups were lower than before surgery,but the observation group was higher than the control group,the level of CD8^(+)in both groups was lower than before surgery,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);before surgery,there was no significant difference in the levels of immunoglobulin G(IGG),serum immunoglobulin A(IGA),serum immunoglobulin M(IGM),complement C3 and complement C4 between the two groups(P>0.05);after surgery,the levels of IGG,IGA and IGM in the control group were lower than those before operation,while the levels of IGG,IGA,IGM,complement C3 and complement C4 in the observation group were higher than those in the control group,with statistical significance(P<0.05).Conclusion:Compared with total hepatic blood flow blockade,semi-hepatic blood flow blockade has less effect on the immune function of primary liver cancer patients undergoing laparoscop

关 键 词：腹腔镜肝切除术 全入肝血流阻断 半肝入肝血流阻断 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤]