肿瘤的分化治疗  

Differentiation therapies in human cancers

作　　者：岳红云 张百红 Yue Hongyun;Zhang Baihong(Department of Ophthalmology,940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730050,China;Department of Oncology,940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院眼科,兰州730050 [2]中国人民解放军联勤保障部队第九四〇医院肿瘤科,兰州730050

出　　处：《国际肿瘤学杂志》2024年第2期109-113,共5页Journal of International Oncology

基　　金：甘肃省自然科学基金(22JR5RA007);联勤保障部队第九四〇医院课题(2021yxky052)。

摘　　要：肿瘤细胞有去分化、分化阻断和转分化3种表型可塑,靶向肿瘤细胞可塑的分化治疗已经成为新的肿瘤治疗模式。肿瘤分化治疗应用诱导分化、启动分化和调控分化促进肿瘤细胞向成熟细胞定向分化和重建正常表型,从而实现肿瘤治疗的目的。Cancer phenotypic plasticity includes dedifferentiation,blocked differentiation and trans-differentiation,and differentiation therapy targeting tumor cell plasticity is becoming a new therapeutic model for human cancers.The application of inducing differentiation,initiating differentiation and regulating differentiation in tumor differentiation therapy will promote the directed differentiation of tumor cells into mature cells and the remodeling of phenotypes,thus to achieve the purpose of cancer treatment.

关 键 词：肿瘤 细胞分化 药物治疗 

分 类 号：R730.5[医药卫生—肿瘤]