卵巢去势后情绪障碍的中西医机制研究  

Research on the mechanism of traditional Chinese and Western medicine in post-ovarian castration mood disorder

作　　者：王丹[1] 张新 Wang Dan;Zhang Xin(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Liaoning Cancer Hospital,Shenyang 110042,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁省肿瘤医院,辽宁沈阳110042

出　　处：《辽宁医学杂志》2024年第2期1-4,共4页Medical Journal of Liaoning

摘　　要：探究妇科肿瘤患者因治疗导致雌激素缺失,引起的一系列情绪障碍的中西医机制。探讨雌激素对HPO生殖轴、5-HT、BDNF和TNF-α的调节作用以阐释卵巢去势后情绪障碍的西医机制。雌激素缺失会导致HPO生殖轴紊乱;雌激素缺失影响5-HT的合成与代谢;雌激素可能通过MEK/ERK-CREB-BDNF通路调节抑郁情绪;雌激素可能通过抑制TNF-α水平而缓解抑郁。从中医角度出发,卵巢去势后肾—天癸—冲任—胞宫轴紊乱,心、肝、肾功能异常导致情绪障碍。本文通过对其发病机制进行综述,为妇科肿瘤患者卵巢去势后情绪障碍的机制研究和治疗提供理论依据。To explore the mechanism of traditional Chinese and Western medicine for a series of mood disorders caused by estrogen deficiency caused by treatment in patients with gynecologic tumors.To investigate the regulatory effect of estrogen on the HPO axis,5-HT,BDNF and TNF-αin order to elucidate the mechanism of post-ovarian castration mood disorder.Estrogen deficiency can lead to HPO axis disorders,estrogen deficiency affects the synthesis and metabolism of 5-HT,estrogen may regulate depression through the MEK/ERK-CREB-BDNF pathway,and estrogen can relieve depression by inhibiting TNF-α.From the perspective of traditional Chinese medicine,after ovarian castration,the kidney-menstruation-Chong and Ren channels-uterus axis will be disordered.and the abnormal heart,liver,and kidney function lead to mood disorders.This article reviews the pathogenesis of gynecological tumors to provide a theoretical basis for the study and treatment of post-ovarian castration mood disorders in patients with gynecologic cancers.

关 键 词：雌激素 抑郁 5-HT BDNF 肾—天癸—冲任—胞宫轴 

分 类 号：R737.3[医药卫生—肿瘤]