呲拉西坦氯化钠注射液联合醒脑静对脑出血患者血肿体积、水肿体积、神经功能评分的影响  

Effect of Piracetam and Sodium Chloride Injection combined with Xingnaojing injection on hema⁃toma volume,edema volume and neurological function score in patients with cerebral hemorrhage

作　　者：郑长瑞 Zheng Changrui(Qixian People′s Hospital,Kaifeng,Henan,Kaifeng,Henan 475200)

机构地区：[1]河南开封杞县人民医院,河南开封475200

出　　处：《辽宁医学杂志》2024年第2期41-44,共4页Medical Journal of Liaoning

摘　　要：目的探讨呲拉西坦氯化钠注射液联合醒脑静对脑出血患者血肿体积、水肿体积、神经功能评分的影响。方法选取我院2019年2月至2022年2月收治的132例脑出血患者,随机分为观察组66例与对照组66例。观察组患者给与呲拉西坦氯化钠注射液和醒脑静联合治疗,对照组患者仅给予醒脑静治疗。比较两组患者治疗前后血肿和水肿体积变化、神经功能评分、日常生活能力评分以及不良反应发生情况。结果与治疗前比较,治疗后两组患者血肿体积、水肿体积均下降(P<0.05),且观察组治疗后血肿(8.19±2.47)mL、水肿(1.72±0.56)mL均低于对照组血肿(12.43±3.64)mL、水肿(2.89±0.76)mL(t=7.831、10.069,P均<0.05);与治疗前比较,治疗后两组患者神经功能评分均下降(P<0.05),日常生活能力评分均升高(P<0.05),且观察组治疗后NIHSS(10.47±3.64)分低于对照组NIHSS(14.89±4.38)分(t=6.305,P<0.05),ADL(67.48±9.36)分高于对照组ADL(58.55±9.74)分(t=5.371,P<0.05);观察组患者不良反应发生率6.06%(4/66)高于对照组3.03%(2/66),但两组比较差异不存在统计学意义(χ^(2)=0.698,P=0.405)。结论呲拉西坦氯化钠注射液和醒脑静联合治疗脑出血患者可有效降低血肿和水肿体积,改善神经功能,提升日常生活能力,且安全性较高,值得推广。Objective To investigate the effect of Piracetam and Sodium Chloride Injection combined with Xingnaojing injection on hematoma volume,edema volume and neurological function score in patients with cerebral hemorrhage.Meth⁃ods A total of 132 patients with cerebral hemorrhage admitted to our hospital from February 2019 to February 2022 were retrospectively selected and randomly divided into the observation group and the control group,with 66 cases in each group.Patients in the observation group were treated with Piracetam and Sodium Chloride Injection and Xingnaojing,and patients in the control group were treated with Xingnaojing only.Hematoma volume,edema volume,neurological function score,activ⁃ities of daily living score and adverse reactions were compared between the two groups before and after treatment.Results Compared with that before treatment,the hematoma volume and edema volume in the two groups decreased after treatment(P<0.05),and the hematoma(8.19±2.47)mL and edema(1.72±0.56)mL in the observation group were lower than those in the control group[(12.43±3.64)mL and(2.89±0.76)mL](t=7.831,10.069,P<0.05).Compared with those before treatment,the neurological function score decreased(P<0.05)and the activities of daily living score increased(P<0.05)in the two groups after treatment,and the NIHSS(10.47±3.64)score in the observation group was lower than that in the control group(14.89±4.38)(t=6.305,P<0.05),while the ADL(67.48±9.36)score was higher than that in the control group(58.55±9.74)(t=5.371,P<0.05).The incidence rate of adverse reactions in the observation group was 6.06%(4/66),higher than that in the control group(3.03%,2/66)(χ^(2)=0.698,P=0.405).Conclusion Pirace⁃tam and Sodium Chloride Injection combined with Xingnaojing in the treatment of patients with cerebral hemorrhage can ef⁃fectively reduce the volume of hematoma and edema,improve neurological function,and improve the ability of daily living of patients,and has high safety.It is worthy of being widely popularized.

关 键 词：脑出血 醒脑静 呲拉西坦氯化钠注射液 血肿体积 水肿体积 神经功能评分 

分 类 号：R743.34[医药卫生—神经病学与精神病学]