基于决策树模型的坤泰胶囊治疗更年期综合征的药物经济学评价  

Pharmacoeconomic Evaluation of Kuntai Capsule in the Treatment of Menopausal Syndrome based on Decision Tree Model

作　　者：王福平 刘毅 崔鑫 谢雁鸣[1] WANG Fu-Ping;LIU Yi;Cui Xin;XIE Yan-Ming(Institute of Basic Medicine in Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中国药物经济学》2024年第3期19-24,共6页China Journal of Pharmaceutical Economics

摘　　要：目的对坤泰胶囊治疗更年期综合征(MS)的经济性进行评价。方法检索中国期刊全文数据库、万方数据知识服务平台、国际卫生技术评估机构网络(INAHTA)以及EMBASE等中英文数据库中关于坤泰胶囊治疗MS的Meta分析,并以卫生体系角度构建坤泰胶囊治疗MS的经济学评价模型,评价坤泰胶囊的经济性。结果本文纳入1项Meta分析,应用Treeage Pro软件构建决策树模型,结果表明:应用坤泰胶囊联合激素治疗MS 90 d的成本和健康产出均高于单用激素治疗,其增量成本-效果比(ICER)为170.65元,即与单用激素治疗相比,坤泰胶囊联合激素疗法每多改善Kupperman评分1分需多花费170.65元。在假定患者的WTP阈值为2022年人均可支配收入的情况下,坤泰胶囊联合激素类药物方案相比单用激素类药物方案更经济。敏感性分析结果表明基础分析结果较稳健。结论坤泰胶囊联合激素疗法较单用激素疗法在改善Kupperman评分方面的经济性更优。Objective To assess the cost-effectiveness of KunTai capsules in treating menopausal syndrome(MS).Methods Meta analysis of Kuntai capsule in MS treatment was searched in Chinese and English databases such as Chinese journal full-text database,Wanfang Data Knowledge Service Platform,International Health Technology Evaluation Agency Network(INAHTA)and EMBASE,and an economic evaluation model of Kuntai capsule in MS treatment was constructed from the perspective of health system to evaluate the economy of Kuntai capsule.Results In this paper,a meta-analysis is included and Treeage Pro software is used to construct a decision tree model.The results show that:The cost and health outcomes of Kuntai capsule combined with hormone therapy for MS 90 d were higher than those of hormone therapy alone,and the incremental cost-effectiveness ratio(ICER)was 170.65 yuan,that is,compared with hormone therapy alone,it cost 170.65 yuan more to improve Kupperman by using Kuntai capsule for each additional 1 minute.Assuming a patient's WTP threshold of 2022 per capita disposable income,Kuntai capsule combined with hormone regimens is more economical than hormone regimens alone.The results of sensitivity analysis show that the results of basic analysis are robust.Conclusion KunTai capsules combined with hormone therapy is more cost-effective than hormone therapy alone in terms of Kupperman symptom score.

关 键 词：药物经济学 决策树模型 坤泰胶囊 上市后评价 更年期综合征 

分 类 号：R711.5[医药卫生—妇产科学] R956[医药卫生—临床医学]