磁性氧化铁纳米粒子应用于胰腺癌靶向诊疗的研究进展  

Progress of magnetic iron oxide nanoparticles in targeted diagnosis and treatment of pancreatic cancer

作　　者：任加强 武帅[1] 莫建涛(综述) 周灿灿[1] 韩亮[1] 仵正(审校)[1] REN Jiaqiang;WU Shuai;MO Jiantao;ZHOU Cancan;HAN Liang;WU Zheng(Department of Hepatobiliary Surgery,First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi Xi’an 710061,China)

机构地区：[1]西安交通大学第一附属医院肝胆外科,陕西西安710061

出　　处：《外科理论与实践》2024年第1期61-66,共6页Journal of Surgery Concepts & Practice

基　　金：陕西省创新能力支撑计划(2022PT-35);陕西省共性技术研发组建(2023GXJS-01-2);校院/企融合创新项目(TQ202210);西安交通大学第一附属医院临床研究课题(XJTU1AF-CRF-2022-034)。

摘　　要：胰腺癌预后极差,其早期诊断和治疗尤为关键。纳米技术已广泛应用于胰腺癌诊治,依靠纳米粒子的独特理化性质和其丰富的表面修饰手段可实现肿瘤部位的有效富集。磁性氧化铁纳米粒子(MIONPs)是胰腺癌诊治常用的纳米材料之一,具有良好的生物相容性。通过对其进行特殊的表面修饰,可应用于胰腺癌的靶向诊断和治疗。MIONPs可作为MRI的对比剂,通过修饰纳米粒子表面,可用于胰腺癌的靶向成像;还可将其改造为载药系统从而实现药物的靶向输送,提高治疗效果等。但是,MIONPs应用于胰腺癌诊疗仍然面临一些挑战,如纳米毒性和成本问题。随着技术发展,MIONPs有望在胰腺癌的个性化诊疗中发挥重要作用。Pancreatic cancer has a very poor prognosis.Early diagnosis and treatment are especially critical for improving its prognosis.Nanotechnology has been widely used in the diagnosis and treatment of pancreatic cancer.Relying on the unique physicochemical properties of nanoparticles and their rich surface modifications,effective enrichment of tumor sites can be achieved.Magnetic iron oxide nanoparticles(MIONPs)is one of the commonly used nanomaterials in the diagnosis and treatment of pancreatic cancer,and has good biocompatibility.Through special surface modification,it can be used in targeted diagnosis and treatment of pancreatic cancer.MIONPs can be used as a contrast agent for MRI,and by modifying the surface,they also can be used in targeted imaging of pancreatic cancer.And they can also be modified as a drug delivery system to achieve targeted delivery of drugs and improve therapeutic effects.However,the application of MIONPs in pancreatic cancer diagnosis and treatment still faces some challenges,such as nanotoxicity and cost issues.With the development of technology,MIONPs are expected to play an important role in the personalized diagnosis and treatment of pancreatic cancer.

关 键 词：胰腺癌 磁性氧化铁纳米粒子 被动靶向 主动靶向 

分 类 号：R735.9[医药卫生—肿瘤]