外周血淋巴细胞亚群计数对晚期不可手术非小细胞肺癌患者预后的影响  

Influence of peripheral blood lymphocyte subsets on prognosis of patients with advanced non-small cell lung cancer

作　　者：许伦[1] 李英[1] 尤玮[2] Xu lun;Li Ying;You Wei(Zigong Fourth People's Hospital,Zigong 643000,China)

机构地区：[1]四川省自贡市第四人民医院肿瘤科,643000 [2]四川省自贡市第四人民医院超声科,643000

出　　处：《现代养生》2023年第15期1154-1157,共4页Health Protection and Promotion

摘　　要：目的探讨治疗前外周淋巴细胞亚群计数对晚期不可手术非小细胞肺癌(NSCLC)患者预后的预测价值。方法收集2018年1月-2020年1月医院确诊的98例Ⅲ~Ⅳ期不可手术的NSCLC患者,并收集同期50名健康体检者作为对照组。检验患者淋巴细胞亚群计数。病例组采用Kaplan-Meier法计算患者总生存期,并用Log-rank检验进行比较。多因素分析采用Cox回归模型,评估治疗前外周血中T淋巴细胞亚群(CD3^(+)T细胞、CD4^(+)T细胞、CD8^(+)T细胞、CD4^(+)/CD8^(+)T细胞)影响晚期不可手术NSCLC患者进展的因素。结果与健康体检者相比,NSCLC患者的CD3^(+)及CD8^(+)明显低于健康对照组,CD4^(+)/CD8^(+)比值、NK细胞明显高于健康对照组,差异均有统计学意义(P<0.05)。多因素Cox回归分析结果表明,患者外周血的CD3^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平对疾病进展有影响(P<0.05)。结论治疗前患者外周血的CD3^(+)、CD8^(+)水平升高,CD4^(+)/CD8^(+)升高是影响患者进展的独立危险因素。Objective To investigate the prognostic value of peripheral lymphocyte subsets before treatment in patients with advanced inoperable non-small cell lung cancer(NSCLC).Methods The clinical characteristics of 98 NSCLC patients diagnosed with stageⅢ-Ⅳnon-surgical NSCLC in the hospital from January 2018 to January 2020 were collected,and 50 healthy individuals in the same period as the control group.Test the patient's lymphocyte subpopulation count.The case group used the Kaplan-Meier method to calculate the total survival time of patients,and compared it with the Log-rank test.Multivariate analysis used Cox regression model to evaluate the factors that affect the progression of advanced non-surgical NSCLC patients with peripheral blood T lymphocyte subsets(CD3^(+)T cells,CD4^(+)T cells,CD8^(+)T cells,CD4^(+)/CD8^(+)T cells)before treatment.Results Compared with healthy individuals undergoing physical examination,the CD3^(+)and CD8^(+)levels in NSCLC patients were significantly lower than those in the healthy control group,while the CD4^(+)/CD8^(+)ratio and NK cells were significantly higher than those in the healthy control group,with statistical significance(P<0.05).The results of multivariate Cox regression analysis showed that the levels of CD3^(+),CD8^(+),CD4^(+)/CD8^(+)in patients'peripheral blood had an impact on disease progression(P<0.05).Conclusion Before treatment,the levels of CD3^(+)and CD8^(+)in the patient's peripheral blood increased,and CD4^(+)/CD8^(+)elevation is an independent risk factor affecting patient progression.

关 键 词：晚期非小细胞肺癌 淋巴细胞亚群 免疫 预后 

分 类 号：R734.2[医药卫生—肿瘤]