外周血炎症细胞因子与脑动脉粥样硬化性狭窄的关系  

Correlation analysis of inflammatory cytokines and cerebral arteriosclerosis stenosis

作　　者：黄双娇 马晓明 盛世英[1] 苑杰 张江 刘猛[1] 岳春贤 Huang Shuangjiao;Ma Xiaoming;Sheng Shiying;Yuan Jie;Zhang Jiang;Liu Meng;Yue Chunxian(The First People's Hospital of Changzhou,Changzhou 213003,China)

机构地区：[1]江苏省常州市第一人民医院神经内科,213003 [2]华北理工大学 [3]华北理工大学精神卫生研究所 [4]华北理工大学附属医院

出　　处：《现代养生》2023年第22期1681-1684,共4页Health Protection and Promotion

基　　金：河北省科技计划项目(编号:152777175);江苏省常州市科技计划资助项目(编号:CJ20220201)。

摘　　要：目的 探讨外周血炎症细胞因子与脑动脉粥样硬化性狭窄(cerebral atherosclerotic stenosis,CAS)的相关性。方法 以2021年6月-2023年3月医院收治的急性脑梗死患者和脑小血管病患者为调查对象,根据头颅MRA/CTA和DSA检查结果将患者分为CAS组(病例组)和血管正常组(对照组)。采用酶联免疫吸附法对血清细胞因子进行检测,比较各细胞因子在两组间分布情况。采用多因素Logistic回归分析分析各因素与CAS的关系,并采用ROC曲线分析各因子水平对CAS的诊断效果。结果 本研究共纳入95名患者,单因素分析显示,卒中史、白细胞介素-2(IL-2)、肿瘤坏死因子-α (TNF-α)、肿瘤坏死因子-γ(TNF-γ)与CAS有关(P<0.05)。多因素Logistic回归分析结果表明IL-2(OR=1.083;95%CI:1.004~1.167,P=0.038)、TNF-α(OR=1.076;95%CI:1.009~1.147,P=0.025)与脑动脉粥样硬化性狭窄有关。ROC曲线分析显示,IL-2在13.08时(AUC=0.726,95%CI:0.623~0.828, P<0.001)、TNF-α在12.78时(AUC=0.683,95%CI=0.577~0.789,P=0.002)有一定的诊断效能,但诊断的灵敏度较低(<50%),漏诊率较高。结论 血清中IL-2、TNF-α水平与脑动脉粥样硬化性血管狭窄有关,当血清中IL-2、TNF-α水平升高,发生脑动脉粥样硬化性血管狭窄的危险性增大。Objective To investigate the relationship between inflammatory cytokines and cerebral atherosclerotic stennsis(CAs)Methods Patiente with cerehral small veccel dicease or acute infarction were collected from 2021.6 to 2023.3.Patients were divided into CAS group and normal vessel group according to MRA/CTA or DSA.Serum cytokines were measured by ELISA and the distribution of cytokines was compared between the two groups.Logistic regression analysis and ROC curve were used to judge the predictive value.Subgroup analysis was performed to compare the distribution of cytokines in different vascular conditions according to the presence of acute cerebral infarction.Multivariate logistic regression analysis was used to analyze the relationship between each factor and CAS,and ROC curve was used to analyze the diagnostic effect of each factor level on CAS.Results A total of 95 patients were included in this study,and multivariate analysis showed that stroke history,interleukin-2(IL-2),tumor necrosis factor-α(TNF-a),tumor necrosis factor-(TNF-)were associated with CAS(P<0.05).The results of multivariate logistic regression analysis showed that IL-2(OR=1.083;95%CI:1.004~1.167,P=0.038)and TNF-α(OR=1.076;95%CI:1.009~1.147,P-0.025)were associated with cerebral atherosclerotic stenosis.ROC curve analysis showed that IL-2 had certain diagnostic efficacy at 13.08(AUC=0.726,95%CI:0.623~0.828,P<0.001)and TNF-αat 12.78(AUC=0.683,95%CI-0.577~0.789,P=0.002),but the diagnostic sensitivity was low(<50%),and the missed diagnosis rate was high.Conclusion The levels of IL-2 and TNF-αin serum are related to cerebral atherosclerotic vascular stenosis,and when the levels of IL-2 and TNF-αin serum increase,the risk of cerebral atherosclerotic vascular stenosis increases.

关 键 词：脑动脉粥样硬化性狭窄 脑梗死 炎症细胞因子 脑小血管病 

分 类 号：R743.1[医药卫生—神经病学与精神病学]