生酮饮食对超重或肥胖多囊肿卵巢综合征治疗效果的Meta分析  

Effect of ketogenic diet on overweight or obese polycystic ovary syndrome:a meta-annaallyyssisis

作　　者：秦思思 赵会新 郝杨 王锐 刘星 李桐 张玉秀 高沛雨 李爽 Hao Yang;Wang Rui;Liu Xing;Li Tong;Zhang Yuxiu;Gao Peiyu;Li Shuang(School of Public Health,North China University of Science and Technology,Tangshan 063000,Chin)

机构地区：[1]华北理工大学公共卫生学院,河北省唐山市063000 [2]华北理工大学附属医院,河北省唐山市063000 [3]华北理工大学护理与康复学院,河北省唐山市063000

出　　处：《现代养生》2023年第10期721-726,共6页Health Protection and Promotion

基　　金：河北省卫生厅医学科学研究重点课题项目(编号:20191113、20201231)。

摘　　要：目的系统评价生酮饮食(ketogenic diet,KD)治疗超重或肥胖多囊卵巢综合征(polycystic ovary syndrome,PCOS)的疗效。方法通过计算机检索Pub Med、EMbase、The Cochrane Library、万方、中国知网和维普期刊数据库,搜集关于KD治疗超重或肥胖PCOS的自身对照或自身对照+随机对照研究的全文文献。检索时限均从建库至2022年10月30日。由2名研究员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.1软件进行Meta分析。结果Meta分析共纳入文献5篇临床疗效研究,共59例患者,均为自身对照研究。分别比较试验前后之间的差异。Meta分析结果显示,与治疗前相比较,治疗后患者体重为WMD=7.01(95%CI:4.37~9.62)、身体质量指数(body mass index,BMI)为WMD=2.76(95%CI:1.63~3.89)、血清总睾酮(total testosterone,TT)水平为WMD=0.07(95%CI:0.02~0.11)、血清促黄体生成素/促卵泡激素比值(total testosterone and luteinizing hormone/follicle stimulating hormone,LH/FSH)为WMD=0.83(95%CI:0.66~0.99);各指标组间差异均有统计学意义(P<0.05)。结论KD可有效和安全地降低PCOS患者体重,改善内分泌指标和生物标志物。受纳入研究质量和数量限制,本结论仍需进一步更多高质量研究加以验证。Objective To systematically evaluate the efficacy of ketogenic diet(KD)in the treatment of overweight or obese polycystic ovary syndrome(PCOS).Methods PubMed,EMbase,The Cochrane Library,WanFang Data,CNKI and ViP databases were searched to collect the full-text literature of self-controlled or self-controlled+randomized controlled studies on the treatment of polycystic tumor syndrome with ketogenic diet.The search time limit was from the establishment of the database to October 30,2022.After two researchers independently screened the literature,extracted the data and evaluated the risk of bias in the included studies,the Rev Men 5.1 software was used for meta-analysis.Results A total of 5 articles were included in this meta-analysis,all of which were self-controlled studies.The differences between before and after the test were compared.Fifty-nine cases of synketogenic diet self control.The results of metaanalysis showed that the improvement of body weight after intervention was WMD-7.01(95%CI:4.37~9.62),the BMI was WMD=2.76(95%CI:1.63~3.89),total testo-sterone WMD=0.07(95%CI:0.02~0.11),total testosterone and luteinizing hormone/follicle stimulating hormone WMD-0.83(95%CI:0.66~0.99).Conclusion The ketogenic diet can effectively and safely reduce body weight and improve endocrine indicators and biomarkers in patients with polycystic tumor syndrome.Limited by the number and quality of included studies,the above conclusions need to be verified by more high-quality studies.

关 键 词：生酮饮食 多囊卵巢综合征 META分析 肥胖 自身对照试验 

分 类 号：R153.1[医药卫生—营养与食品卫生学]