宏基因二代测序在异基因造血干细胞移植后军团菌肺炎的6例临床应用观察  

Clinical application of metagenomic next generation sequencing technology for Legionella pneumonia after allogeneic hematopoietic stem cell transplantation:a report of 6 cases

作　　者：夏晶[1] 蒋军红[2] 赵晔[1] 马骁[1] 吴德沛[1] 陈苏宁[1] 陈峰[1] Xia Jing;Jiang Junhong;Zhao Ye;Ma Xiao;Wu Depei;Chen Suning;Chen Feng(Department of Hematology,The First Affiliated Hospital of Soochow University,Jiangsu Institute of Hematology,National Clinical Research Center for Hematologic Diseases,Suzhou 215006,China;Department of Respiratory and Critical Care Medicine,Dushu Lake Hospital Affiliated to Soochow University,Suzhou 215127,China)

机构地区：[1]苏州大学附属第一医院血液科,江苏省血液研究所,国家血液系统疾病临床医学研究中心,苏州215006 [2]苏州大学附属独墅湖医院呼吸与危重症医学科,苏州215127

出　　处：《中华器官移植杂志》2024年第2期119-121,共3页Chinese Journal of Organ Transplantation

基　　金：国家重点研发计划(22YFC2502700);江苏省血液病医学创新中心(CXZX202201)。

摘　　要：本文报告了2019年9月至2023年7月在苏州大学附属第一医院采用宏基因二代测序(metagenomic next generation sequencing,mNGS)诊断的6例异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)后军团菌肺炎受者的诊治情况。军团菌感染是造血干细胞移植术后少见的机会性感染,诊断不易,早期诊断可取得更好的预后。mNGS检测为临床提供早期精准诊断可能,值得应用和推广。This review described the clinical data of 6 recipients with Legionella pneumonia after allogeneic hematopoietic stem cell transplantation(allo-HSCT)through metagenomic next generation sequencing(mNGS)from September 2019 to July 2023 at First Affiliated Hospital of Soochow University.The clinical characteristics and treatment outcomes were retrospectively examined.Legionella infection is a rare opportunistic infection after allo-HSCT.A definite diagnosis is rather difficult and an earlier diagnosis yields a better prognosis.As an early and accurate diagnostic tool for clinical practice,mNGS detection is worthy of wider applications.

关 键 词：造血干细胞移植 军团菌肺炎 基因测序 

分 类 号：R457.7[医药卫生—治疗学] R563.1[医药卫生—临床医学]