视网膜静脉阻塞继发黄斑水肿的光相干断层生物学 标志物的研究进展  

Research progress of optical coherence tomography biomarkers in macular edema secondary to retinal vein occlusion

作　　者：刘俊茹 董微莉[1] Liu Junru;Dong Weili(Department of Ophthalmology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China)

机构地区：[1]承德医学院附属医院眼科,承德067000

出　　处：《中华眼底病杂志》2024年第5期397-401,共5页Chinese Journal of Ocular Fundus Diseases

摘　　要：视网膜静脉阻塞(RVO)是最常见的致盲性视网膜血管疾病之一,常继发黄斑水肿(ME),从而造成患者严重的视功能损害。RVO继发ME(RVO-ME)视网膜和脉络膜改变中的光相干断层扫描生物学标志物在RVO-ME患者的病情评估、疗效评价、视力预测等方面有重要的临床价值,其中视网膜内层结构紊乱、外界膜和椭圆体带的完整性、黄斑中心凹视网膜厚度改变是评价视力预后的可靠指标;强反射点、视网膜下液和视网膜内液可作为反映炎症水平的重要参数;中界膜征和急性黄斑旁中心中层视网膜病变是判断视网膜缺血程度的客观依据;脉络膜血管指数和脉络膜厚度变化也在评估病情进展方面存在潜在的优势。准确地把握RVO-ME相关光相干断层生物学标志物的特点,有利于其在RVO-ME临床诊断和治疗中的合理、精准运用,并有助于进一步深入探究该疾病的发病机制。Retinal vein occlusion(RVO)is one of the most common retinal vascular diseases causing blindness,macular edema(ME)is often secondary to it,which causes serious visual impairment to patients.Imaging biomarkers in the changes of retina and choroid of ME secondary to RVO(RVO-ME)have important clinical value in the evaluation of condition,curative effect and visual acuity prediction of patients with RVO-ME.Among them,the disorganization of the retinal inner layers,the integrity of external limiting membrane and ellipsoid zone,and the change of central macular thickness are reliable indexes to evaluate the prognosis of visual acuity;hyperreflective foci,subretinal fluid and intraretinal fluid can be used as important parameters to reflect the level of inflammation;prominent middle limiting membrane and paracentral acute middle maculopathy are the objective basis for judging the degree of retinal ischemia;the changes of choroidal vascular index and choroidal thickness also have potential advantages in evaluating the progress of the disease.Accurately grasp the characteristics of biological markers of RVO-ME related optical coherence tomography is conducive to its reasonable and accurate use in the clinical diagnosis and treatment of RVO-ME,and helpful to further explore the pathogenesis of the disease.

关 键 词：视网膜静脉阻塞 黄斑水肿 体层摄影术 光学相干 综述 

分 类 号：R774.1[医药卫生—眼科]