子宫内膜癌组织PROX1、FABP6表达及与临床病理特征的相关性研究  

Expression of PROX1 and FABP6 in endometrial cancer tissue and their correlation with clinical pathological characteristics

作　　者：潘溯 李锐 牛红雁 PAN Su;LI Rui;NIU Hongyan(Department of Gynecology,the First People’s Hospital of Yunnan Province,Kunming,Yunnan 650000,China;Department of Obstetrics and Gynecology,Kunming City Maternal and Child Health Hospital,Kunming,Yunnan 650000,China)

机构地区：[1]云南省第一人民医院妇科,云南昆明650000 [2]昆明市妇幼保健院妇二科,云南昆明650000

出　　处：《中国优生与遗传杂志》2024年第3期471-475,共5页Chinese Journal of Birth Health & Heredity

摘　　要：目的探究子宫内膜癌(EC)组织Prospero相关同源异形盒蛋白1(PROX1)、脂肪酸结合蛋白6(FABP6表达及与临床病理特征的相关性。方法以2018年2月至2020年2月在云南省第一人民医院诊治的96例EC患者为EC组,收集根治性手术切除的癌组织。同时期收集手术过程中获取的正常子宫内膜组织96例;比较癌组织及正常子宫内膜组织中PROX1和FABP6表达;分析PROX1、FABP6与临床病理的相关性及影响EC患者预后的危险因素。结果相较于正常组织,EC癌组织中PROX1、FABP6表达水平显著升高(P<0.05);肌层浸润深度≥1/2、肿瘤直径≥2 cm、FIGO分期Ⅲ~Ⅳ期、病理分级G2~G3、有淋巴结转移EC患者癌组织中PROX1、FABP6阳性表达比例高于肌层浸润深度<1/2、肿瘤直径<2 cm、FIGO分期Ⅰ~Ⅱ期、病理分级G1、无淋巴结转移患者(P<0.05);PROX1与FABP6阳性表达患者总生存率均显著低于阴性表达患者总生存率(P<0.05);FIGO分期(Ⅲ~Ⅳ)、有淋巴结转移、PROX1和FABP6阳性表达均是影响EC患者预后的危险因素。结论EC患者癌组织中PROX1、FABP6表达水平显著升高,两者与临床病理特征及患者预后密切相关。Objective To investigate the expression of prospero-related homeobox protein 1(PROX1)and fatty acid binding protein 6(FABP6)in endometrial cancer tissue and their correlation with clinical pathological characteristics.Methods A total of 96 EC patients diagnosed and treated in the First People’s Hospital of Yunnan Province from February 2018 to February 2020 were selected as the EC group,and the cancer tissues resected by radical surgery were collected.During the same period,96 cases of normal endometrial tissue were collected during the surgery(normal tissue).The expression of PROX1 and FABP6 in cancer tissues and normal endometrial tissues was compared.The correlation between PROX1,FABP6 and clinicopathology and the risk factors affecting the prognosis of EC patients were analyzed.Results Compared with normal tissues,the expression levels of PROX1 and FABP6 in EC cancer tissues were significantly increased(P<0.05).The positive expression rates of PROX1 and FABP6 in cancer tissues of EC patients with depth of muscle invasion≥1/2,tumor diameter≥2 cm,FIGO stageⅢ‒Ⅳ,pathological grading G2-G3,and lymph node metastasis were higher than those of EC patients with depth of muscle invasion<1/2,tumor diameter<2 cm,FIGO stageⅠ‒Ⅱ,pathological grading G1,and non lymph node metastasis(P<0.05).The overall survival rate of patients with positive expression of PROX1 and FABP6 was significantly lower than that of patients with negative expression(P<0.05).FIGO staging(Ⅲ-Ⅳ),lymph node metastasis,positive expression of PROX1,and positive expression of FABP6 were all risk factors affecting the prognosis of EC patients.Conclusion The expression levels of PROX1 and FABP6 in cancer tissues of EC patients were significantly increased,which were closely related to clinicopathological features and prognosis of patients.

关 键 词：子宫内膜癌 Prospero相关同源异形盒蛋白1 脂肪酸结合蛋白6 病理特征 

分 类 号：R737.33[医药卫生—肿瘤]