线粒体铁死亡与中枢神经系统退行性疾病  

Mitochondrial ferroptosis and degenerative diseases of the central nervous system

作　　者：孙若寒 许静[2] 吕佩源[2] 董艳红[2] Sun Ruohan;Xu Jing;Lyu Peiyuan;Dong Yanhong(Graduate Academy of Hebei Medical University,Shijiazhuang 050017,China;Department of Neurology,Hebei General Hospital Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学研究生学院,石家庄050017 [2]河北省人民医院神经内科,河北省脑网络与认知障碍重点实验室,石家庄050051

出　　处：《中华行为医学与脑科学杂志》2024年第4期369-373,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家科技创新2030—"脑科学与类脑研究"重大项目(2021ZD0201807);河北省自然科学基金(H2020307042,H2022307075)。

摘　　要：铁死亡是一种与细胞凋亡、自噬及坏死不同的新型细胞死亡方式。线粒体作为细胞内能量代谢的主要细胞器,参与铁稳态的调节,在神经退行性疾病铁死亡的发病机制中起着关键作用。本文总结了在铁死亡发生机制中线粒体所发挥的作用,尤其是小胶质细胞和星形胶质细胞中线粒体铁死亡机制,并探讨了中枢神经系统退行性疾病与线粒体铁死亡之间的关系,为疾病提供切实可行的治疗策略。Ferroptosis is a novel form of cell death which is different from apoptosis,autophagy,and necrosis.As the main organelle for intracellular energy metabolism,mitochondria participates in the regulation of iron homeostasis and plays a key role in the pathogenesis of ferroptosis in neurodegenerative diseases.This review provides a preliminary summary of the role of mitochondria in the pathogenesis of ferroptosis,especially the mechanism of ferroptosis in microglia and astrocytes,and explores the relationship between degenerative diseases of the central nervous system and mitochondrial ferroptosis in order to provide practical treatment strategies for these diseases.

关 键 词：铁死亡 线粒体 中枢神经系统 退行性疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]