精神分裂症纹状体神经影像学研究进展  

Progress in neuroimaging of striatum in schizophrenia

作　　者：李婉怡 张荣荣[2] 申旭冉 闫伟[2] 杜经纶[2] 谢世平[2] Li Wanyi;Zhang Rongrong;Shen Xuran;Yan Wei;Du Jinglun;Xie Shiping(The Fourth School of Clinical Medicine,Nanjing Medical University,Nanjing 210029,China;Department of Psychiatry,Affiliated Nanjing Brain Hospital,Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第四临床医学院,南京210029 [2]南京医科大学附属脑科医院精神科,南京210029

出　　处：《中华行为医学与脑科学杂志》2024年第4期374-378,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家重点研发计划项目(2016YFC1306800);江苏省南京市卫生科技发展专项资金项目计划(ZKX21033)。

摘　　要：纹状体作为大脑核心区域,与大脑多个脑区构成复杂网络,参与多项功能如大脑信息整合、奖赏学习、运动等。不少研究表明,精神分裂症患者纹状体存在不同程度结构改变,另有相关研究发现,精神分裂症患者纹状体与其他脑区、默认网络、视觉网络、奖赏网络等存在功能连接异常,而这些异常可能与精神分裂症的认知障碍、幻觉妄想、快感缺失等相关。本文主要介绍精神分裂症纹状体的结构及功能磁共振成像的最新研究进展,为更好理解精神分裂症患者神经生物学发病机制提供参考。As a core region of the brain,the striatum forms a complex network with various brain regions,and is involved in many functions,such as brain information integration,reward learning,sports and so on.Many studies have shown that the striatum of patients with schizophrenia has structural changes to varying degrees,and other relevant studies have found that the striatum of patients with schizophrenia has functional connectivity abnormalities with other brain regions,default network,visual network,reward network,etc.,and these abnormalities may be related to cognitive disorders,hallucinations,anhedonia and other aspects of schizophrenia.In this review,the structure of the striatum in schizophrenia and the recent advances in functional magnetic resonance imaging are reviewed,so as to provide a reference for understanding the neurobiological mechanism of schizophrenia patients.

关 键 词：精神分裂症 结构磁共振成像 功能磁共振成像 纹状体 神经影像学 

分 类 号：R749.3[医药卫生—神经病学与精神病学]