Targeted nanostrategies eliminate pre-metastatic niche of cancer  

作　　者：Juan Wang Ning Zhang Xiuping Ding Chengrui Fu Xiaodong Li Baosheng Li Jianxun Ding Tianmeng Sun 

机构地区：[1]Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education,Institute of Immunology,The First Hospital,Jilin University,1 Xinmin Street,Changchun 130061,China [2]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,5625 Renmin Street,Changchun 130022,China [3]Department of Radiation Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,440 Jiyan Road,Jinan 250117,China [4]Department of orthopaedics,The Second Hospital of Shandong University,Shandong University,247 Beiyuan Street,Jinan 250033,China [5]State Key Laboratory of Molecular Engineering of Polymers,Fudan University,220 Handan Road,Shanghai 200433,China

出　　处：《Nano Research》2024年第6期5358-5373,共16页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.82325029,U23A20591,U22A20156,52273158,82102845,52173149,and 52022095);the Shandong Province Innovation Platform Projects(No.2021LCZX04);the Academic Promotion Program of Shandong First Medical University(No.2019LJ004);the Shandong Natural Science Foundation Major Basic Research Project(No.ZR2022ZD31);the Shandong Province Traditional Chinese Medicine Science and Technology Program(No.Z-2022075);the Shandong Province Natural Science Foundation(No.ZR2020MH090).

摘　　要：Establishing a pre-metastatic niche(PMN)in secondary organs is a prerequisite for cancer metastases.Despite advances in cancer therapy,the efficient inhibition of PMN formation remains a clinical challenge.Recent advances in understanding the specific characteristics of PMN and advances in nanotechnology have provided hope for manipulating their microenvironments.A series of nanostrategies have been designed to eliminate the PMN,including the removal of pro-metastatic exosomes from the bloodstream for excretion via the intestines,the targeting and scavenging of myeloid-derived suppressor cells,fibroblasts,and critical extracellular matrix components,and the elimination of circulating tumor cells prior to colonization in distant organs.This review summarizes the underlying mechanisms of PMN formation,highlights the anti-PMN efficacy of currently reported nanostrategies,and underlines the unresolved questions.

关 键 词：nanoparticle controlled drug delivery pre-metastatic niche elimination metastasis suppression cancer therapy 

分 类 号：R73-37[医药卫生—肿瘤]