Rational design of biodegradable semiconducting polymer nanoparticles for NIR-II fluorescence imaging-guided photodynamic therapy  

作　　者：Xuxuan Gu Jinlong Shen Zhiwei Xu Wenqi Wang Ying Wu Wen Zhou Chen Xie Quli Fan 

机构地区：[1]State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM),Nanjing University of Posts&Telecommunications,9 Wenyuan Road,Nanjing 210023,China

出　　处：《Nano Research》2024年第6期5399-5408,共10页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22174070 and 22205115);Natural Science Foundation of Jiangsu Province(No.BK20230060);Natural Science Foundation of Jiangsu University(No.21KJB150022);the Research startup fund of NJUPT(No.NY220149);Natural Science Foundation of NJUPT(No.NY221088);the Project of State Key Laboratory of Organic Electronics and Information Displays,Nanjing University of Posts and Telecommunications(Nos.GZR2022010012 and GZR2023010022);the Synergetic Innovation Center for Organic Electronics and Information Displays for the financial support.

摘　　要：Semiconducting polymer nanoparticles(SPNs)have shown great promise in second near-infrared window(NIR-II)phototheranostics.However,the issue of long metabolic time significantly restricts the clinical application of SPNs.In this study,we rationally designed a biodegradable SPN(BSPN50)for NIR-II fluorescence imaging-guided photodynamic therapy(PDT).BSPN50 is prepared by encapsulating a biodegradable SP(BSP50)with an amphiphilic copolymer F-127.BSP50 is composed of NIR-II fluorescent diketopyrrolopyrrole(DPP)segment and degradable poly(phenylenevinylene)(PPV)segment with the ratio of 50/50.BSPN50 has both satisfactory degradability under myeloperoxidase(MPO)/hydrogen peroxide(H_(2)O_(2))and NIR-II fluorescence emission upon 808 nm laser excitation.Furthermore,BSPN50 shows good photodynamic efficacy under 808 nm laser irradiation.BSPN50 shows a faster degradation rate than BSPN100 which has no PPV segment both in vitro and in vivo.In addition,BSPN50 can effectively diagnose tumor via NIR-II fluorescence imaging and inhibit the tumor growth by PDT.Thus,our study provides a rational approach to construct biodegradable nanoplatforms for efficient tumor NIR-II phototheranostics.

关 键 词：near-infrared(NIR)-II fluorescence imaging semiconducting polymer nanoparticles photodynamic therapy tumor imaging 

分 类 号：R730.5[医药卫生—肿瘤] TB383[医药卫生—临床医学]