线粒体DNA与心血管疾病相关性的研究进展  

Research progress on correlation between mitochondrial DNA and coronary heart disease

作　　者：冯露 尤雅丽 杨倩[1] 王立立[1] Feng Lu;You Yali;Yang Qian;Wang Lili(Department of Cardiology,Hebei General Hospital,Shijiazhuang 050057,China)

机构地区：[1]河北省人民医院心血管内科,石家庄050057

出　　处：《中华老年多器官疾病杂志》2024年第5期394-397,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：河北省政府资助临床医学优秀人才基金(ZF2023190)。

摘　　要：线粒体作为人体的能量工厂,具有自己独立的基因组——线粒体DNA(mtDNA)。心肌作为一种高耗能组织,线粒体的正常供能至关重要,而mtDNA在一定程度上可以影响线粒体的供能。根据最新的全球疾病负担研究,心血管疾病(CVD)是导致死亡的主要原因,冠心病是CVD患者主要的死亡原因之一。mtDNA作为一种新发现的生物标志物,与冠心病的发生机制、潜在的治疗靶点、对预后的预测等具有很强的关联性,本文就mtDNA与冠心病相关性的研究进展进行综述。Mitochondria,as body′s energy factory,have their own separate genome—mitochondrial DNA(mtDNA).Normal energy supply of mitochondria is of great importance to myocardium,a high energy consuming tissue,while mtDNA can affect the energy supply of mitochondria to a certain extent.According to the latest Global Burden of Disease study,cardiovascular disease(CVD)is the top cause of death,and coronary heart disease(CHD)is one of the leading causes of death for CVD patients.As a newly discovered biomarker,mtDNA has a strong correlation with the pathogenesis,potential therapeutic targets and prognosis of CHD.In this article,we review the research progress of the correlation between mtDNA and CHD.

关 键 词：线粒体DNA 线粒体功能障碍 MTDNA突变 冠心病 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]