L-茶氨酸口溶膜的制备及其成膜条件的优化  

Preparation of L-theanine Orodispersible Film and Optimization of Its Film-forming Conditions

作　　者：曲超楠 李木子 李林珏 赵晓娜[1] 刘永夏[1] 戴培强 刘建柱[1] QU Chao-nan;LI Mu-zi;LI Lin-jue;ZHAO Xiao-na;LIU Yong-xia;DAI Pei-qiang;LIU Jian-zhu(College of Animal Science and Technology,Shandong Agricultural University,Tai'an,Shandong,271000,China;Shandong Deerta Bioengineering Co.,LTD.,Tai'an,Shandong,271000,China)

机构地区：[1]山东农业大学动物科技学院,山东泰安271000 [2]山东戴尔塔生物工程有限公司,山东泰安271000

出　　处：《动物医学进展》2024年第7期60-63,共4页Progress In Veterinary Medicine

摘　　要：茶氨酸是茶叶中特征性的非蛋白质类氨基酸,具有抗应激、稳定情绪、改善睡眠、增强免疫力和抗炎等多种药理作用。试验旨在制备L-茶氨酸口溶膜,并评价其质量。采用流延法制备L-茶氨酸口溶膜,通过单因素试验法和正交试验法对制备所需的L-茶氨酸含量、羟丙基甲基纤维素含量、甘油含量、烘箱温度和干燥时间进行探索,优化成膜处方成分配比和制备条件。结果显示,L-茶氨酸口溶膜最佳配比为L-茶氨酸0.5 g、HPMC 1.8 g、甘油0.5 mL、钛白粉0.02 g与12 mL水混合,最佳干燥条件为60℃干燥100 min,其物理性能、L-茶氨酸含量及重量差异等指标均满足要求,有望为宠物临床用药提供数据支持。Theanine is a characteristic non-proteinogenic amino acid which has anti-stress,stabilizing emotions,sleep improvement,immune regulation,anti-inflammatory and other pharmacological actions in tea plants.This experiment aims to fabricate the L-theanine orodispersible film and evaluate the quality.The content of L-theanine,HPMC and glycerol,oven temperature,drying time were explored by single factor test and orthogonal test.The composition ratio and preparation conditions of the film forming prescription were optimized.The experiment results showed that the optimum ratio of L-theanine orodispersible film was L-theanine 0.5 g,HPMC 1.8 g,glycerol 0.5 mL,titanium dioxide 0.02 g mixed with 12 mL water,and the optimum drying condition was drying at 60℃for 100 min.The physical properties,L-theanine content and weight variation meet the requirements,which was expected to provide data support for pet clinical medication.

关 键 词：茶氨酸 口溶膜剂 流延法 制备工艺 

分 类 号：S859.799.9[农业科学—临床兽医学]