纯钛表面载锌聚多巴胺涂层改性及其抗腐蚀性能初探  

Modification of zinc-doped polydopamine coating on pure titanium surface and its corrosion resistance:A preliminary study

作　　者：梅煜坤 张建兰[1] 邱憬[1] MEI Yukun;ZHANG Jianlan;QIU Jing(Department of Oral Implantology,The Affiliated Stomatological Hospital of Nanjing Medical University,Jiangsu Province Key Laboratory of Oral Diseases,Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing 210029,China)

机构地区：[1]南京医科大学附属口腔医院种植科,江苏省口腔疾病研究重点实验室,江苏省口腔转化医学工程研究中心,江苏南京210029

出　　处：《口腔医学》2024年第5期356-361,共6页Stomatology

基　　金：国家自然科学基金面上项目(82271003);国家自然科学基金青年项目(82201096);江苏高校“青蓝工程”中青年学术带头人项目;江苏省科教能力提升工程——江苏省研究型医院建设单位(YJXYYJSDW4);江苏省医学创新中心(CXZX202227)。

摘　　要：目的在纯钛表面制备载锌聚多巴胺涂层,并探究其生物相容性及抗腐蚀性能。方法将纯钛试件先后浸泡在多巴胺碱性溶液与硫酸锌溶液中,在试件表面形成载锌聚多巴胺涂层。以光滑钛表面以及聚多巴胺涂层改性钛表面为对照组,载锌聚多巴胺涂层改性钛表面为实验组。采用扫描电镜观察试件表面微形貌,X线能谱仪表征锌元素在聚多巴胺涂层上的结合。采用接触角测量仪检测试件表面的亲水性。体外培养L-929成纤维细胞,通过CCK-8评价改性钛表面的生物相容性。采用电化学工作站获取各组试件在人工唾液中的开路电位和极化曲线,分析载锌聚多巴胺涂层对钛表面抗腐蚀性能的影响。结果扫描电镜和X线能谱仪分析结果显示,3组试件表面的微形貌均有差异,载锌聚多巴胺涂层组试件表面有锌元素存在。涂层修饰后试件表面的亲水性增强。体外细胞实验显示,载锌聚多巴胺涂层具有良好的生物相容性。电化学测试获得的开路电位和动态极化曲线及其拟合数据显示,载锌聚多巴胺涂层组试件的抗腐蚀性能最强,聚多巴胺涂层组次之,光滑钛组最小。结论采用化学浸泡法可在钛表面成功制备载锌聚多巴胺涂层,改性钛表面具有良好的生物相容性和抗腐蚀性能。Objective To prepare zinc-loaded polydopamine coating on the surface of pure titaniumand investigate its biocompatibility and corrosion resistance.Methods Pure titanium specimens were successively immersed in a dopamine alkaline solution and a zinc sulfate solution to form a zinc-loaded polydopamine coating on the surface of the specimens.The smooth titanium surface and the polydopamine-coatedtitanium surface were used as the control group,and the zinc-containing polydopamine-coated titanium surface was used as the experimental group.Scanning electron microscopy(SEM)was used to observe the micro-morphology of the specimen surface,and energy dispersive spectrometer(EDS)was used to determine the binding of zinc elements on the polydopamine coating.The hydrophilicity of the specimen surface was detected by a contact angle meter.L-929 fibroblasts were cultured in vitro and the biocompatibility of the modified titanium surface was evaluated by CCK-8 assay.An electrochemical potentiostat was used to obtain the open-circuit potential and potentiodynamic polarization curves of specimens of each group in artificial saliva to analyze the effect of zinc-doped polydopamine coating on the corrosion resistance of titanium surface.Results SEM and EDS analyses showed that there were differences in the surface micro-morphology among three groups,and the presence of zinccould be detected on the surface of the specimens in the zinc-doped polydopamine coating group.The hydrophilicity of the specimen surface was enhanced after coating modification.The results of in vitro experiment revealed that the zinc-doped polydopamine coating had good biocompatibility.The open-circuit potential and potentiodynamic polarization curves obtained from electrochemical tests and their fitting data showed that the zinc-doped polydopamine coating group had the strongest corrosion resistance,followed by the polydopamine coating group,and the smooth titanium group had the smallest.Conclusion Zinc-doped polydopamine coatingscanbe successfully prepared on t

关 键 词：聚多巴胺 锌 钛表面 抗腐蚀性能 

分 类 号：R783.2[医药卫生—口腔医学]