还原型谷胱甘肽联合核苷类似物治疗乙肝肝硬化的临床分析  

Clinical Analysis of Reduced Glutathione Combined with Nucleoside Analogues in the Treatment of Hepatitis B Cirrhosis

作　　者：张沛枫[1] ZHANG Peifeng(Department of Infectious Disease,Nantong Third People's Hospital,Nantong,Jiangsu Province,226000 China)

机构地区：[1]南通市第三人民医院传染科,江苏南通226000

出　　处：《中外医疗》2024年第10期18-21,共4页China & Foreign Medical Treatment

摘　　要：目的探究乙型肝炎(简称乙肝)肝硬化患者应用还原型谷胱甘肽联合核苷类似物治疗的效果。方法随机选取2020年2月—2023年2月南通市第三人民医院收治的60例乙肝肝硬化患者为研究对象,采用盲摸双色球法分为研究组、参照组,各30例。参照组行常规治疗,研究组采用还原型谷胱甘肽联合核苷类似物治疗。比较两组临床疗效、肝纤维化程度、肝功能及不良反应发生情况。结果干预前,两组肝纤维化程度、肝功能水平比较,差异无统计学意义(P均>0.05)。干预后,研究组临床治疗总有效率(96.67%)高于参照组(80.00%),差异有统计学意义(χ^(2)=4.043,P<0.05)。干预后,研究组肝纤维程度中层粘连蛋白(Laminin,LN)、透明质酸(Hyaluronic,HA)及Ⅳ型胶原(Ⅳ-collagen,Ⅳ-C)水平均低于参照组,差异有统计学意义(P均<0.05)。干预后,研究组肝功能水平中总胆红素(Total Bilirubin,TBIL)、白蛋白(Albumin,ALB)、谷丙转氨酶(Glutamic Pyruvic Transaminase,GPT)及谷草转氨酶(Glutamic Oxaloacetic Transaminase,GOT)水平均优于参照组,差异有统计学意义(P均<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论乙肝肝硬化患者应用还原型谷胱甘肽联合核苷类似物治疗能够提高其治疗效果,改善肝纤维化程度及肝功能水平,且安全性较高。Objective To explore the therapeutic effect of reduced glutathione combined with nucleoside analogues in patients with hepatitis B cirrhosis.Methods 60 patients with hepatitis B cirrhosis admitted to Nantong Third People's Hospital from February 2020 to February 2023 were randomly selected as the study objects.They were divided into the study group and the reference group by the method of blind touch double color ball,with 30 cases in each group.The reference group received conventional treatment,while the study group received glutathione combined with nucleoside analogues.The clinical efficacy,degree of liver fibrosis,liver function and occurrence of adverse reactions were compared between groups.Results Before intervention,there was no statistically significant difference in the degree of liver fibrosis and liver function levels between the two groups(both P>0.05).After intervention,the total effective rate of clinical treatment in the study group(96.67%)was higher than that in the reference group(80.00%),and the difference was statistically significant(χ^(2)=4.043,P<0.05).After intervention,the levels of laminin(LN),hyaluronic acid(HA),and type Ⅳ collagen(Ⅳ-C)in the liver fibrosis degree of the study group were lower than those of the reference group,and the differences were statistically significant(all P<0.05).After intervention,the total bilirubin(TBIL),albumin(ALB),glutamic pyruvic transaminase(GPT),and glutamic oxaloacetic transaminase(GOT)levels in the liver function of the study group were better than those of the reference group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Treatment with reduced glutathione combined with nucleoside analogues can improve the therapeutic effect,the degree of liver fibrosis and the level of liver function in patients with hepatitis B cirrhosis,with high safety.

关 键 词：还原型谷胱甘肽 核苷类似物 乙肝肝硬化 临床疗效 肝纤维化程度 肝功能 

分 类 号：R575[医药卫生—消化系统]