早期癫痫患者用卡马西平联合丙戊酸钠治疗效果与安全性分析  

Analysis of Efficacy and Safety of Carbamazepine Combined with Sodium Valproate in the Treatment of Patients with Early Epilepsy

作　　者：李坤 尘丹 穆卫卫 LI Kun;CHEN Dan;MU Weiwei(Department of Neurology,Shanxian Central Hospital,Heze,Shandong Province,274300 China)

机构地区：[1]山东省单县中心医院神经内科,山东菏泽274300

出　　处：《中外医疗》2024年第10期122-126,共5页China & Foreign Medical Treatment

摘　　要：目的分析单一用药(卡马西平)与联合用药(丙戊酸钠+卡马西平)方案对早期癫痫疾病的作用。方法随机选取2020年6月—2023年12月山东省单县中心医院神经内科收治的100例早期癫痫患者为研究对象,以临床落实治疗措施不同分为两组,单一用药组50例(卡马西平),联合用药组50例(丙戊酸钠+卡马西平)。比较两组患者的疗效、安全性、基本治疗指标、认知功能、氧化应激水平、神经传导速度差异。结果干预后,联合用药组治疗有效度、认知功能评分、超氧化物歧化酶高于单一用药组,丙二醛、过氧化物酶低于单一用药组,神经传导速度快于单一用药组,差异有统计学意义(P均<0.05);两组患者不良反应总发生率比较,差异无统计学意义(P>0.05);联合用药组每日癫痫发作频次少于单一用药组,持续时间短于单一用药组,差异有统计学意义(P均<0.05)。结论早期癫痫的形成对于患者的机体健康、生活及工作等方面非常不利,为达到高效且安全的治疗目的建议采用丙戊酸钠+卡马西平方案,此方案既可改善氧化应激水平,还可提高患者的认知功能,治疗效果满足临床需求。Objective To analyze the effects of single administration(carbamazepine)and combined administration(sodium valproate+carbamazepine)on early epilepsy.Methods A total of 100 patients with early-stage epilepsy admitted to the Department of Neurology of Shanxian Central Hospital of Shandong Province from June 2020 to December 2023 were randomly selected as the study objects.According to the clinical implementation of treatment measures,they were divided into two groups,with 50 cases in the single drug group(carbamazepine)and 50 cases in the combined drug group(sodium valproate+carbamazepine).The efficacy,safety,basic therapeutic indexes,cognitive function,oxidative stress level and nerve conduction velocity were compared between the two groups.Results After the intervention,the therapeutic effectiveness,cognitive function score and superoxide dismutase in the combined drug group were higher than those in the single drug group,the malondialdehyde and peroxidase were lower than those in the single drug group,and the nerve conduction speed was faster than that in the single drug group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The daily frequency and duration of seizures in the combined medication group were less than those in the single medication group,and the differences were statistically significant(both P<0.05).Conclusion The formation of early epilepsy is very unfavorable to the health,life and work of patients.In order to achieve efficient and safe treatment,it is recommended to use sodium valproate+carbamazepine.This regimen can not only improve the level of oxidative stress,but also improve the cognitive function of patients,and the therapeutic effect meets the clinical needs.

关 键 词：联合用药 治疗效果 丙戊酸钠 早期癫痫 卡马西平 安全性 

分 类 号：R742[医药卫生—神经病学与精神病学]