氨酚曲马多片联合普瑞巴林胶囊对癌性神经病理性疼痛及睡眠质量的影响分析  

Analysis of the Impact of Acetaminophen/Tramadol Tablets Combined with Pregabalin Capsules on Cancerous Neuropathic Pain and Sleep Quality

作　　者：谢炉峰 冯江[1] XIE Lufeng;FENG Jiang(Oncology Department of Zigong Fourth People′s Hospital,Zigong 643000,China)

机构地区：[1]四川省自贡市第四人民医院肿瘤科,自贡643000

出　　处：《世界睡眠医学杂志》2024年第3期496-498,共3页World Journal of Sleep Medicine

摘　　要：目的:探讨普瑞巴林胶囊联合氨酚曲马多片治疗癌性神经病理性疼痛的疗效及对患者睡眠质量的影响。方法:选取2021年2月至2023年2月四川省自贡市第四人民医院肿瘤科癌性神经病理性疼痛患者56例进行回顾性分析,根据治疗方法分为对照组和观察组,每组28例。对照组采用普瑞巴林胶囊治疗,观察组采用普瑞巴林胶囊与氨酚曲马多片联合治疗。观察2组爆发痛次数、疼痛程度、不良情绪、睡眠质量、临床疗效以及不良反应。结果:观察组患者的爆发痛次数少于对照组(P<0.05),静息疼痛评分、运动疼痛评分、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、MOS睡眠量表(MOS-SS)中综合睡眠障碍指数(9-items)、睡眠干扰(SLPD)评分均低于对照组(均P<0.05),睡眠量(SLPQ)、睡眠充足度(SLPA)评分均高于对照组(均P<0.05)。观察组患者总有效率为92.86%,对照组总有效率为71.43%,观察组总有效率高于对照组(P<0.05)。观察组不良反应发生率为21.43%,对照组不良反应发生率为17.86%,2组不良反应发生率比较差异无统计学意义(P>0.05)。结论:普瑞巴林胶囊与氨酚曲马多片联合治疗癌性神经病理性疼痛的疗效较单独普瑞巴林胶囊疗效更好,且能改善患者的睡眠质量。Objective:To investigate the efficacy of pregabalin capsules combined with acetaminophen/tramadol tablets in treating cancerous neuropathic pain and their impact on patients′sleep quality.Methods:A retrospective analysis was conducted on 56 patients with cancerous neuropathic pain in the Oncology Department of Zigong Fourth People′s,Sichuan Province,from February 2021 to February 2023.Based on the treatment method,patients were divided into a control group and an observation group,with 28 cases in each group.The control group received treatment with pregabalin capsules,while the observation group received a combined treatment of pregabalin capsules and acetaminophen/tramadol tablets.The two groups were observed for the number of breakthrough pain episodes,pain intensity,adverse emotions,sleep quality,clinical efficacy,and adverse reactions.Results:The number of breakthrough pain episodes in the observation group was less than that in the control group(P<0.05).The scores for resting pain,movement pain,Hamilton Anxiety Rating Scale(HAMA),Hamilton Depression Rating Scale(HAMD),and the composite sleep disturbance index(9-items)and sleep disruption(SLPD)from the MOS Sleep Scale(MOS-SS)were all lower in the observation group than in the control group(P s<0.05).Sleep quantity(SLPQ)and sleep adequacy(SLPA)were higher in the observation group(P s<0.05).The total effective rate was 92.86%in the observation group and 71.43%in the control group,with the observation group having a higher overall effectiveness rate(P<0.05).The incidence of adverse reactions was 21.43%in the observation group and 17.86%in the control group,with no significant difference between the two groups(P>0.05).Conclusion:The combined treatment of pregabalin capsules and acetaminophen/tramadol tablets for cancerous neuropathic pain is more effective than pregabalin capsules alone and can improve patients′sleep quality.

关 键 词：癌性神经病理性疼痛 氨酚曲马多片 普瑞巴林胶囊 疼痛 心理状态 睡眠质量 疗效 不良反应 

分 类 号：R741.05[医药卫生—神经病学与精神病学]