产单核细胞李氏杆菌噬菌体的应用研究进展  

Research Progress of Applied Research on Listeria monocytogenes Phage

作　　者：崇倩 赵学慧 曹青 薛惠文[1] 苟惠天[1] CHONG Qian;ZHAO Xuehui;CAO Qing;XUE Huiwen;GOU Huitian(College of Veterinary Medicine of Gansu Agricultural University,Lanzhou 730070,China)

机构地区：[1]甘肃农业大学动物医学院,兰州730070

出　　处：《畜牧兽医学报》2024年第5期1819-1826,共8页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(32060822,31960726,31560700);国家重点研发计划(2019YFC1605705)。

摘　　要：产单核细胞李氏杆菌是一种常见的食源性致病菌,其致死率高达30%。该菌能够在高盐度、高酸度和冷藏温度等极端条件下存活和增殖,对人畜健康构成了重大威胁。然而抗生素的滥用导致药物残留和多重耐药性等问题的出现,从而使得李氏杆菌病的防治异常困难。噬菌体相关生物制剂的发展为解决以上问题提供了可行方案。本文综述了李氏杆菌噬菌体在食品保鲜、生物检测、基因工程等方面的应用,同时还探讨了噬菌体与宿主之间的互作机制,旨在为李氏杆菌噬菌体在食品污染防控中提供一定的理论依据。Listeria monocytogenes being a common foodborne pathogen.Food contaminated with this bacterial can cause listeriosis,with clinical manifestations of sepsis and meningitis,and mortality be up to 30%.Listeria monocytogenes can survive under extreme condition such as high salinity,high acidity,and low temperature,so posing a significant threat to the human and animal health.At present,the main method of preventing and treating this disease is the use of antibiotics.However,the multiple drug resistance making the prevention and treatment of listeriosis extraordinarily difficult.The development of phage and related biological agents provides feasible solutions to solve the above problem.This article reviews the applications of Listeria phages in food preservation,biological detection,genetic engineering,and the interaction between phages and hosts,aiming to provide a theoretical basis for Listeria phages in food pollution prevention and control.

关 键 词：李氏杆菌 噬菌体 食品污染 生物检测 

分 类 号：S852.61[农业科学—基础兽医学]