升清降浊化脂汤结合艾灸治疗肝郁脾虚湿困型非酒精性脂肪性肝炎患者的效果  

Effect of Shengqing Jiangzhuo Huazhi Decoction combined with moxibustion in the treatment of non-alcoholic steatohepatitis with liver depression and spleen deficiency and dampness stagnation

作　　者：余敬先 王松猫 江丽慧 谢永忠 王春喜 YU Jingxian;WANG Songmao;JIANG Lihui;XIE Yongzhong;WANG Chunxi(The Third Ward(Department of Hepatology),Shangrao Second People's Hospital,Jiangxi Province,Shangrao334000,China;Department of Traditional Chinese Medicine,Shangrao Xinzhou District Second People's Hospital,Jiangxi Province,Shangrao334000,China)

机构地区：[1]江西省上饶市第二人民医院3病区(肝病科),江西上饶334000 [2]江西省上饶市信州区第二人民医院中医科,江西上饶334000

出　　处：《中国当代医药》2024年第14期63-66,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0130)。

摘　　要：目的探讨升清降浊化脂汤结合艾灸治疗肝郁脾虚湿困型非酒精性脂肪性肝炎(NASH)患者的效果。方法选取2022年1月至2023年4月上饶市第二人民医院收治的300例肝郁脾虚湿困型NASH患者为研究对象,按照随机数字表法分为对照组(n=150)和观察组(n=150)。对照组采用水飞蓟宾、多烯磷脂酰胆碱治疗,观察组采用升清降浊化脂汤结合艾灸治疗。比较两组患者的中医证候积分、肝功能指标、血脂指标、不良反应。结果治疗后,观察组的大便溏稀[(0.28±0.05)分]、周身困重[(0.15±0.03)分]、腹胀[(0.37±0.14)分]、食欲不振[(0.83±0.06)分]评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的丙氨酸转氨酶[(57.84±5.52)U/L]、总胆红素[(33.81±2.79)μmol/L]、天冬氨酸转氨酶[(50.61±6.22)U/L]、三酰甘油[(2.01±0.42)mmol/L]、胆固醇[(4.32±0.51)mmol/L]均低于对照组,差异有统计学意义(P<0.05)。观察组的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论在肝郁脾虚湿困型NASH患者中应用升清降浊化脂汤结合艾灸治疗效果佳,能够肝功能改善,下调血脂指标,且不良反应少,安全性高。Objective To investigate the effect of Shengqing Jiangzhuo Huazhi Decoction combined with moxibustion in the treatment of non-alcoholic steatohepatitis(NASH)with liver depression and spleen deficiency and dampness stagnation.Methods A total of 300 patients with NASH of liver depression and spleen deficiency and dampness stagnation admitted to Shangrao Second People's Hospital from January 2022 to April 2023 were selected as the study objects,and they were divided into control group(n=150)and observation group(n=150)according to random number table method.The control group was treated with Silymarin and Polyene Phosphatidyl Choline,and the observation group was treated with Shengqing Jiangzhuo Huazhi Decoction combined with moxibustion.The traditional Chinese medicine syndrome scores,liver function indexes,blood lipid indexes and adverse reactions were compared between the two groups.Results After treatment,the scores of loose stool([0.28±0.05]points),feeling trapped and heavy all over the body([0.15±0.03]points),abdominal distension([0.37±0.14]points)and loss of appetite([0.83±0.06]points)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the alanine transaminase([57.84±5.52]U/L),total bilirubin([33.81±2.79]μmol/L),aspartate transaminase([50.61±6.22]U/L),triglyceride([2.01±0.42]mmol/L),cholesterol([4.32±0.51]mmol/L)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Shengqing Jiangzhuo Huazhi Decoction combined with moxibustion is effective in the treatment of NASH patients with liver depression and spleen deficiency and dampness stagnation,which can improve liver function,down-regulate blood lipid indexes,and has fewer adverse reactions and high safety.

关 键 词：非酒精性脂肪性肝炎 肝郁脾虚湿困型 升清降浊化脂汤 艾灸 肝功能 

分 类 号：R575.1[医药卫生—消化系统]