EWSR1-FLI1通过代谢重编程影响尤文肉瘤发生发展的研究进展  

EWSR1-FLI1 affects the development and progression of Ewing’s sarcoma through metabolic reprogramming:research progress

作　　者：赵薇 江润益 江爱民[3] 龚海熠 魏海峰 ZHAO Wei;JIANG Runyi;JIANG Aimin;GONG Haiyi;WEI Haifeng(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Department of Orthopaedic Oncology,The Second Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200003,China;Department of Urology,The First Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]海军军医大学(第二军医大学)第二附属医院骨肿瘤科,上海200003 [3]海军军医大学(第二军医大学)第一附属医院泌尿外科,上海200433

出　　处：《海军军医大学学报》2024年第5期620-626,共7页Academic Journal of Naval Medical University

基　　金：国家自然科学基金(82072971).

摘　　要：尤文肉瘤是发生于儿童和青少年的第二常见恶性原发性骨肿瘤,该病恶性程度极高,患者病程短,转移事件发生快,严重危害儿童和青少年的健康。肿瘤细胞通过一系列复杂的调控机制促进包括糖、氨基酸、脂类等在内的营养物质发生代谢重编程,进而维持肿瘤高代谢状态,促进肿瘤发生、发展;同时代谢重编程相关产物可作用于肿瘤微环境中各细胞组分,抑制肿瘤免疫反应,甚至诱导耐药事件的发生。尤文肉瘤断裂区域1(EWSR1)-佛氏白血病病毒整合蛋白1(FLI1)融合蛋白是尤文肉瘤的关键促癌分子,具有多重功能和复杂的调控机制,了解EWSR1-FLI1对尤文肉瘤细胞代谢变化的影响及其相关调控机制,可为探究尤文肉瘤的病因、寻找有效的诊疗靶点及治疗策略提供线索。本文就EWSR1-FLI1影响尤文肉瘤代谢重编程的相关研究进展进行汇总与剖析,旨在为该病的早期诊断和精准治疗提供新的思路。Ewing’s sarcoma is the second most common malignant primary bone tumor in children and adolescents,marked by its exceptional malignancy,abbreviated patient course,and rapid metastasis,posing a substantial threat to the health of children and adolescents.Tumor cells promote metabolic reprogramming of nutrients including sugars,amino acids,lipids,and more through a series of complex regulatory mechanisms,thus maintaining the high metabolic state of tumor and promoting tumor development.The products related to metabolic reprogramming exert a significant impact on various cellular constituents in the tumor microenvironment,inhibiting anti-tumor immune responses,and even inducing drug resistance events.A pivotal player in this context is the Ewing sarcoma breakpoint region 1(EWSR1)-Friend leukemia virus integration 1(FLI1)fusion protein,which assumes multifaceted roles with intricate regulatory mechanisms.Understanding the specific metabolic changes and regulatory pathways orchestrated by EWSR1-FLI1 in Ewing’s sarcoma cells holds the promise of shedding light on the disease’s etiology.Additionally,this knowledge offers a path to the discovery of novel diagnostic and therapeutic markers and strategies.This article summarizes and analyzes the recent research progress of EWSR1-FLI1 on metabolic reprogramming in Ewing’s sarcoma,providing new ideas for the early diagnosis and precise treatment of the disease.

关 键 词：骨软骨瘤 尤文肉瘤 代谢重编程 EWSR1-FLI1 

分 类 号：R738[医药卫生—肿瘤]