吸入暴露途径下纳米塑料在SD大鼠体内的富集特征研究  

Study on the accumulation characteristics of nanoplastics in SD rats under inhalation exposure route

作　　者：董小艳[1] 杨波 谢颖 李明姣 陈嘉禾 李浩然[5] 阮鸿洁[1] 王琼[1] DONG Xiaoyan;YANG Bo;XIE Ying;LI Mingjiao;CHEN Jiahe;LI Haoran;RUAN Hongjie;WANG Qiong(China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention;Beijing Shunyi District Center for Disease Control and Prevention;School of Public Health,Xuzhou Medical University;School of Ecology and Environment,Inner Mongolia University;School of Resource and Environmental Engineering,Inner Mongolia University of Technology)

机构地区：[1]中国疾病预防控制中心环境与人群健康重点实验室,中国疾病预防控制中心环境与健康相关产品安全所 [2]北京顺义区疾病预防控制中心 [3]徐州医科大学公共卫生学院 [4]内蒙古大学生态与环境学院 [5]内蒙古工业大学资源与环境工程学院

出　　处：《环境工程技术学报》2024年第3期764-768,共5页Journal of Environmental Engineering Technology

基　　金：国家自然科学基金项目(42177418)。

摘　　要：为探讨吸入暴露纳米级塑料在生物体呼吸系统以外组织上的富集特征,以100 nm聚苯乙烯微球对SD大鼠进行2 h短期吸入暴露,使用热裂解-气相色谱质谱法测定大鼠肝脏、肾脏、心脏以及脑组织上的聚苯乙烯浓度。结果显示:暴露组大鼠肾脏、心脏和肝脏中的浓度[(0.416±0.143)、(0.633±0.278)和(0.617±0.179)g/g]显著高于对照组大鼠[(0.249±0.020)、(0.070±0.096)和(0.101±0.140)g/g],差异具有统计学意义(P<0.05),但各组织间的相关性不显著(P>0.05);2组大鼠脑组织均未检出聚苯乙烯。研究表明,100 nm聚苯乙烯微球吸入暴露2 h后,可通过肺泡进入血液循环,进而在大鼠肝脏、肾脏、心脏中形成沉积。通过探讨纳米级塑料在生物体内的累积特征,为深入开展吸入纳米塑料对人体的健康影响研究提供数据支撑。To explore the accumulation of respiratory nanoplastics in tissues out of respiratory system,the 100 nm polystyrene nanoplastics were used to perform a 2h-short term uptake exposure to SD rats,and the polystyrene concentrations in liver,kidney,heart,and brain of rats were determined with pyrolysis-gas chromatography/mass spectrometry(Py-GC/MS).The results showed that the concentrations in the kidney,heart,and liver of the exposure group[(0.416±0.143),(0.633±0.278),and(0.617±0.179)g/g]were significantly higher than those of the control group[(0.249±0.020),(0.070±0.096),and(0.101±0.140)g/g](P<0.05),but no significant correlation were found among different tissues(P>0.05),and polystyrene was not detected in the brain of both the control and exposure groups.The results show that the nanoplastics can enter the blood circulation of rats through the alveoli and deposit in tissues such as liver,kidney,and heart shortly after 2 h of inhalation exposure of 100 nm polystyrene nanoplastics.The study preliminarily explored the accumulation characteristics of nanoplastics in organisms,and could provide data support for further research on the potential impacts of respiratory nanoplastics on human health.

关 键 词：聚苯乙烯纳米塑料 吸入暴露 SD大鼠 热裂解-气相色谱质谱 

分 类 号：X50[环境科学与工程—环境工程]