EBNA1-IgG抗体阳性患者免疫功能与肝功能损害的关系分析  

Correlation between Immune Function and Hepatic Impairment in EBNA-1 IgG-positive Patients

作　　者：马春红 王珂[1] 李艳[1] Ma Chun-hong;Wang Ke;Li Yan(Department of Clinical Laboratory,Zhengzhou First Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第一人民医院检验科,河南郑州450000

出　　处：《四川生理科学杂志》2024年第5期1047-1049,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探究EBNA1-IgG抗体阳性患者免疫功能变化与肝功能损害的关系。方法:选取2020年4月至2023年4月于我院就诊的78例EBNA1-IgG抗体阳性患者为研究对象。根据肝功能是否受损分为肝功能正常患者为观察组(44例)和肝功能异常患者为对照组(34例)。比较两组患者空腹血清免疫球蛋白(IgM、IgG和IgA)水平和白细胞计数(White Blood Cell Count,WBC)、淋巴细胞计数(Lymphocyte count,Lym)、中性粒细胞计数(Neutrophil count,NEUT)。采用Pearson相关性分析EBNA1-IgG抗体阳性患者免疫功能变化与肝功能损害的相关性。分析EBNA1-IgG抗体阳性患者肝功能损害的危险因素。结果:观察组IgM、IgG、IgA均低于对照组,其中IgG和IgA差异具有统计学意义(P<0.05),IgM差异无统计学意义(P>0.05)。观察组WBC、Lym和NEUT指标低于对照组,差异具有统计学意义(P<0.05)。Pearson相关分析结果显示,EBNA1-IgG抗体阳性患者肝损伤与IgG、IgA、WBC、Lym和NEUT呈正相关。Logistic回归分析显示,Lym(OR=1.612,95%CI:1.056~2.459)为EBNA1-IgG抗体阳性患者合并肝功能损伤的独立危险因素。结论:EBNA1-IgG抗体阳性患者免疫功能变化与肝功能损害密切相关。Objective:To investigate the correlation between immune function and hepatic impairment in Epstein-Barr virus nuclear antigen-1(EBNA-1)immunoglobulin G(IgG)-positive patients.Methods:Seventy-eight EBNA-1 IgG-positive patients in our hospital from April 2020 to April 2023 were selected,and assigned into observation group(n=44)and control group(n=34)according to the absence or presence of hepatic impairment.The fasting serum immunoglobulin(IgM,IgG and IgA)levels,White Blood Cell Count(WBC),Lymphocyte count(Lym)and Neutrophil count(Neut)was compared between the two groups.Pearson correlation analysis was used to analyze the correlation between immune function changes and liver function damage in patients with EBNA1-IgG antibody positive.To analyze the risk factors of liver function damage in patients with EBNA1-IgG antibody positive.Results:IgM,IgG and IgA in observation group were lower than those in control group,and the difference between IgG and IgA was statistically significant(P<0.05),while IgM was not statistically significant(P>0.05).The indexes of WBC,Lym and NEUT in observation group were lower than those in control group,and the difference was statistically significant(P<0.05).Pearson correlation analysis denoted that the occurrence of hepatic impairment in EBNA-1 IgG-positive patients was positively correlated with IgG,IgA,WBC,Lym and NEUT.Logistic regression analysis indicated that Lym(OR=1.612,95%CI:1.056~2.459)was an independent risk factor for hepatic impairment in EBNA-1 IgG-positive patients.Conclusion:The changes of immune function in EBNA-1 IgG-positive patients are closely related to occurrence of hepatic impairment.

关 键 词：EBNA1-IgG抗体阳性 EB病毒 免疫功能 肝功能 

分 类 号：R575[医药卫生—消化系统]