内镜下黏膜切除术治疗消化道难治性息肉患者的疗效研究  

Clinical efficacy of endoscopic mucosal resection in patients with refractory polyps of the digestive tract

作　　者：毛璐 高瑞华 李发印 Mao Lu;Gao Rui-hua;Li Fa-yin(Department of Gastroenterology,General Hospital of Jinshui District,Zhengzhou 450000,China)

机构地区：[1]郑州市金水区总医院消化内科,河南郑州450000

出　　处：《四川生理科学杂志》2024年第5期1050-1052,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探究内镜下黏膜切除术治疗消化道难治性息肉患者疗效。方法:回顾性收集本院2021年9月至2023年9月期间收治的89例消化道难治性息肉患者临床资料,依据不同手术方法分为对照组(行内镜下高频电切术,n=44)和研究组(行内镜下黏膜切除术,n=45)。比较两组手术指标和术后消化道功能,手术前后以酶联免疫法检白细胞介素-12(Interleukin-12,IL-12)、白细胞介素-17(Interleukin-17,IL-17)、白细胞介素-1β(Interleukin-1β,IL-1β)水平;以视觉模拟评分(Visual analogue scales,VAS)评估疼痛程度,于术后统计两组并发症。结果:与对照组相比,研究组住院时间、出血量均显著减少(P<0.05)。与对照组相比,研究组消化道功能恢复较快(P<0.05)。术后,研究组血清炎症因子水平低于对照组(P<0.05);与对照组相比,研究组术后疼痛感较轻(P<0.05)。两组术后并发症总发生率无显著差异(P>0.05)。结论:消化道难治性息肉患者行内镜下黏膜切除术能促进消化道功能恢复,减轻机体炎症反应,减轻术后疼痛感,促进患者快速恢复。Objective:To explore the efficacy of endoscopic mucosal resection in the treatment of refractory polyps of the digestive tract.Methods:The clinical data of 89 patients with refractory polyps of the digestive tract admitted to our hospital from September 2021 to September 2023 were retrospectively collected,and were divided into a control group(endoscopic high-frequency electroreception,n=44)and a study group(endoscopic mucosal resection,n=45)according to different surgical methods.The surgical indexes and postoperative digestive tract function were compared between the two groups,the levels of Interleukin-12(IL-12),Interleukin-17(IL-17),and Interleukin-1β(IL-1β)before and after the surgery were measured by enzyme-linked immunoassay,and the level of pain was assessed by visual analogue scales(VAS).The postoperative complications were counted in both groups.Results:Compared with the control group,the length of hospital stay and the amount of blood loss in the study group were significantly reduced(P<0.05).Compared with the control group,the recovery of digestive tract function in the study group was significantly accelerated(P<0.05).After the operation,the levels of serum inflammatory factors in the study group were significantly lower than those in the control group(P<0.05).Compared with the control group,the postoperative pain in the study group was significantly reduced(P<0.05).There was no significant difference in the total incidence of postoperative complications between the two groups(P>0.05).Conclusion:Endoscopic mucosal resection in patients with refractory polyps of the digestive tract can promote the recovery of digestive tract function,reduce the level of serum inflammatory factors,relieve postoperative pain,and promote rapid recovery of patients with good safety.

关 键 词：消化道难治性息肉 炎症因子 消化道功能 高频电切术 黏膜切除术 

分 类 号：R735[医药卫生—肿瘤]